Difference Between Avastin and Lucentis (With Table)

In today’s world, there are several mediums of harmful rays generated. For example, mobiles and computers strike out harmful radiations as well as rays that affect our eyes and brain for the long term. These rays cause eyes irritation and brain abnormality like lack of sleep, anxiety issues, etc. Sometimes permanent loss of eye vision can also happen if precautions are not taken in the early stage.

Avastin and Lucentis are brands that sell medicines related to eye problems and other types of diseases such as cancer. Mainly bevacizumab is sold by the trade name Avastin, and similarly, ranibizumab is sold by the trade name Lucentis. Avastin stays for a long time in systematic circulation as compared to Lucentis, which shows that Avastin is more powerful.

Avastin vs Lucentis 

The difference between Avastin and Lucentis is that Avastin is fully antibody type which means they have large chains of proteins made out of B-cells. It mostly targets vascular endothelial protein growth. While Lucentis is an antigen-binding fragment type which means that it mostly sticks to a region of antigens. And develops high bonding to vascular endothelial proteins as compared to Lucentis.

Avastin is a liquid medication that goes into our bodies through injections. This medication treats several types of cancers like lung cancers, breast cancers, brain cancers, and renal cancers, etc. During the treatment process, bevacizumab which is a product of Avastin, is injected into a patient’s veins. Several other brands like Zirabev, Mvasi, etc., also sell this medication.

Lucentis is a fab fragment medication that sticks to antigens to develop immunity and protein in our body. This medication is used to treat eye problems caused by diabetes, retinal diseases due to old age, and macular degeneration. The main purpose of this drug is to decrease the growth of unusual blood vessels in the eyes and to prevent discharge from these vessels.

Comparison Table Between Avastin and Lucentis

Parameters of Comparison AvastinLucentis
Type and medication Avastin is a brand name or trade name for the medication bevacizumab and it is fully antibody type which means it acts as a whole molecule. Lucentis is a trading name for the medication ranibizumab which is of antigen-binding fragment class.
UsesAvastin is used to treat diseases like cancers including lung cancers, breast cancers, brain cancers, etc, and also for eye problems. Lucentis is mainly used to treat eye problems that come with increasing age like vascular retinal disease, vision loss, etc.
Side effects Avastin may cause side effects during the treatment process and side effects include breathing problems, high blood pressure, and nose bleeding, etc. Lucentis also have side effects which include watery eyes, dry eyes, sinus pain, and blurred vision, etc.
Glycosylation Avastin products perform glycosylation reactions in which carbohydrates get attached to hydroxyl to produce glycoconjugate. Lucentis does not perform a glycosylation reaction.
Half-lifeAvastin has more half-life which is around 18 to 21 days which means it reduces to its original value in 18 to 21 days. Lucentis takes about three days to get reduce to its original value.

What is Avastin?

Avastin is a drug brand that provides cures for both cancer and retinal problems. It sells bevacizumab, and mostly this medication is known by its brand name that is Avastin. Bevacizumab boosts immunity during cancer treatments as it is made up of immunity cells. Avastin produces or boosts the growth of antiangiogenic agents present in the body.

During the treatment of tumors, Avastin works on tumor growth cells and stops their further growth by terminating those blood vessels, which helps the tumor to grow by providing sufficient oxygen, vitamins, and nutrients to it. This drug is a whole antibody type of drug and targets vascular growth factor A in the human body. It relaxes the muscles and boosts energy.

Avastin, when compared to Lucentis, is less expensive. But the total expenses depend on the type of disease a patient has.

What is Lucentis?

Lucentis mainly treats all types of eye-related infections and diseases. Mainly ranibizumab is known in the markets by its brand names Lucentis and Byooviz. It is a fab fragment type of drug that builds the growth of antigens in the body. Antigens are substances or molecules that help the immune system to develop antibodies against foreign invaders that can make the immune system weak.

The source of this drug is humanized, which means it is made up of non-human species. Genentech was the first biotechnology corporation who make this drug, and it was first marketed in the United States of America. It treats both age-related as well as diabetic retinal issues like diabetic retinopathy, vision loss, macular degeneration, and blurred vision, etc.

Lucentis’s main work is to terminate the growth of new abnormal cells or blood vessels present in the eye that may lead to leakage in the eye. This drug is injected into the eye directly.

Main Differences Between Avastin and Lucentis

  1. Avastin is a brand name or trade name for the medication bevacizumab, and it is fully antibody type which means it acts as a whole molecule. On the other hand, Lucentis is a trading name for the medication ranibizumab which is of antigen-binding fragment class.
  2. Lucentis takes about three days to get reduce to its original value. Whereas Avastin has more half-life which means it reduces to its original value in 18 to 21 days.
  3. Lucentis is mainly used to treat eye problems that come with increasing age like vascular retinal disease, vision loss, etc. While Avastin is used to treat diseases like cancers including lung cancers, breast cancers, brain cancers, etc, and also for eye problems.
  4. Avastin causes side effects during the treatment process and side effects include breathing problems, high blood pressure, and nose bleeding, etc. Whereas Lucentis also have side effects which include watery eyes, dry eyes, sinus pain, and blurred vision, etc.
  5. Avastin products perform glycosylation reactions in which carbohydrates get attached to hydroxyl to produce glycoconjugate, But Lucentis does not perform these types of reactions.

Conclusion

Many body problems come when our age increases because as age increases, our body parts stop functioning properly and with efficiency. Therefore medications are provided by the doctors that stop the growth of abnormal new cells and increase the growth of immunity-building cells. But these medications include so many side effects which take action during the treatment process.

Avastin is very costly as compared to Lucentis because it is used in various cancer treatments like lung cancer, brain cancer or tumor, etc. The doses also vary according to the type of disease. Lucentis’s main ingredient is ranibizumab which is mainly used for retinal problems caused by diabetes as well as old age of a person. Avastin can also be used for retinal problems but in low-level cases.

References

  1. https://www.sciencedirect.com/science/article/pii/S0006291X05011344
  2. https://www.sciencedirect.com/science/article/pii/S0161642007010305
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