Loestrin vs Loestrin Fe: Difference and Comparison

With the increasing population, contraceptives and birth control pills are a boon. There are numerous ways to avoid unplanned pregnancies, but the birth control pill is the most prominent.


Health Quiz

Test your knowledge about topics related to health

1 / 10

What is the best way to maintain a healthy weight?

2 / 10

What is the role of carbohydrates in our diet?

3 / 10

What is the main cause of sleep apnea?

4 / 10

Which of the following is NOT a symptom of depression?

5 / 10

What is the best way to improve sleep quality?

6 / 10

The parts of the body that work together to change food into a form the body can use.

7 / 10

It takes ____ to keep your mind alert.

8 / 10

What is the main cause of chronic obstructive pulmonary disease (COPD)?

9 / 10

What is the best exercise for overall health?

10 / 10

Many children with asthma experience more severe reactions when they breathe ___________________.

Your score is


But as umpteen pills are available in the market, it may perplex the common man. One such example is Loestrin and Loestrin Fe, both perform the same function of controlling unwanted pregnancies but carry some subtle differences. Knowing their differences and side effects may assist in choosing them.  

Key Takeaways

  1. Both Loestrin and Loestrin Fe are combination birth control pills containing the hormones estrogen and progestin.
  2. Loestrin Fe includes iron supplementation in the form of ferrous fumarate, while Loestrin does not.
  3. Women taking Loestrin Fe may experience less severe menstrual bleeding due to the added iron supplementation.

Loestrin vs. Loestrin Fe  

Loestrin is a low-dose pill used to prevent pregnancy, regulate menstrual cycles, reduce menstrual cramps, and decrease the risk of ovarian cysts. Loestrin FE contains 20 micrograms of ethinyl estradiol and norethindrone as progestin hormones, but also contains ferrous fumarate, which is an iron supplement.

Loestrin vs Loestrin Fe

Loestrin is a type of contraceptive pill consisting of 21 pills plus 7 pills without hormones. It is a perfect combination of the hormones- Norethindrone and Ethinyl Estradiol.

Loestrin belongs to the class of drugs called Hormonal Contraceptives. It is primarily manufactured by Duramed Pharmaceuticals.   

On the other hand, Loestrin Fe is a birth control pill that contains 21 pills plus 7 pills with iron. Typically, Loestrin Fe is the brand name of a drug that contains many other sub-categories in the form of other drugs.

It falls under the category/ class of Combination Progesterone and Estrogen Contraceptives.   

Comparison Table

Parameters of Comparison   Loestrin    Loestrin Fe  
Type    Generic Drug    Brand Name with Sub-Types
Norethindrone and Ethinyl Estradiol content Usually, 1/20   Varies- 1/20 or 1.5/30
Course/ Dosage 21 pills + 7 pills  Varies- 21 pills + 7 pills  or 24 pills + 4 pills
Additional Ingredients in Placebo PillsAbsent    Present- Fe- Iron  
Side Effects  Acne, Headache, Weight Gain, etc.    Headache, Darker Stools, etc.  

What is Loestrin?  

As mentioned, Loestrin is a generic birth control pill that falls under hormonal contraceptives primarily used to control unplanned pregnancies. Although it has minor side effects, it remains one of the most widely used pills.   

Loestrin is a combination of natural hormones like progesterone and estrogen that primarily works to stop the ovulation of the eggs. This halt in ovulation helps to stop the eggs from maturing and thus eventually stopping pregnancy.   

This progesterone and estrogen combination, scientifically known as Norethindrone (Progesterone) and Ethinyl Estradiol (Estrogen), primarily alters the endometrial lining of the uterus and the cervical mucus making the uterus unsuitable for implantation and pregnancy.   

Loestrin contains 21 pills with active hormonal ingredients and 7 with no active hormonal ingredients. Doctors and Practitioners advise continuously taking one pill daily, with or without food.

The doses remain the same for all age groups of women irrespective of their age, weight, etc.   

A continuous dosage of Loestrin can cause minor side effects like headache, acne, weight gain, breast tenderness, nausea, and bleeding between menstrual cycles.

Women with smoking habits and hypertension are strictly prohibited from taking this medicine as it can lead to clots, strokes, heart attacks, etc.

Women under medication, supplements, or any treatment are advised not to take this medicine as it may not work under their influence. Although Loestrin has certain conditions and side effects, it is one of the most prescribed drugs in the United States. 

What is Loestrin Fe?   

As mentioned above, Loestrin Fe is a type of contraceptive pill that falls under a Combination of Progesterone and Estrogen Contraceptives that primarily work to stop ovulation, thus avoiding unplanned pregnancies.

Loestrin Fe has many subcategories or types popularly known as forms of Loestrin Fe.   

Loestrin Fe contains 21 pills with active hormonal ingredients, and the additional 7 pills (called placebo pills) contain iron. The Fe in Loestrin Fe is derived from Iron/ Ferrous Fumarate.

There is a single exception of Loestrin Fe, which is Loestrin 24 Fe which contains 24 active pills.   

Loestrin Fe also contains the same Norethindrone (Progesterone) and Ethinyl Estradiol (Estrogen) but in different quantities than the rest of the pills.

For instance, a single pill of Loestrin Fe consists of approximately 20- 30 micrograms of Ethinyl Estradiol and 1 milligram, although it can vary with different brands.  

Loestrin Fe comes in three forms: Loestrin Fe 1/20, Loestrin Fe 1.5/30, and Loestrin 24 Fe. These numbers signify the amount of Norethindrone and Ethinyl Estradiol in a single pill.

Loestrin 24 Fe contains 24 active pills with additional 4 pills (placebo pills) containing iron.   

Just like any other birth control pill, Loestrin Fe also carries the same side effects like headache, weight gain, etc. Also, women suffering from hypertension and medications and alcohol/ smoking habits should avoid this pill.

One minor side effect of Loestrin Fe is the dark stools due to the presence of Iron as an additional ingredient. Thus, it is advised to take Loestrin Fe with an additional Vitamin C supplement for better absorption of Fe (Iron).  

Main Differences Between Loestrin and Loestrin Fe  

  1. Loestrin is a generic contraceptive pill/ drug. On the other hand, Loestrin Fe is a brand name with certain sub-types/ forms.   
  2. The course of Loestrin is 21 pills plus 7 pills with no additional ingredients. In contrast, the course of Loestrin Fe is 21 pills plus 7 pills with iron. Peculiarly, Loestrin 24 Fe contains 24 pills plus 4 placebo pills.    
  3. Loestrin comes in 1/20, signifying the amount of Norethindrone and Ethinyl Estradiol. On the other hand, Loestrin Fe comes in 3 forms- Loestrin Fe 1/20, Loestrin 1.5/30, and Loestrin 24 Fe.   
  4. Loestrin has side effects like acne, headache, etc. In contrast, Loestrin Fe carries a side effect of dark stools due to the presence of iron.  
  5. Loestrin does not require any additional supplement, whereas it is advised to take Vitamin C supplement with Loestrin Fe.  


  1. https://www.sciencedirect.com/science/article/pii/S0010782406003179 
  2. https://www.sciencedirect.com/science/article/pii/S0010782401002141 


One request?

I‚Äôve put so much effort writing this blog post to provide value to you. It‚Äôll be very helpful for me, if you consider sharing it on social media or with your friends/family. SHARING IS ‚ô•ÔłŹ

Want to save this article for later? Click the heart in the bottom right corner to save to your own articles box!

Ads Blocker Image Powered by Code Help Pro

Ads Blocker Detected!!!

We have detected that you are using extensions to block ads. Please support us by disabling these ads blocker.