Deoxyribonucleic acid is abbreviated as DNA. DNA is a complex molecule as long as three billion letters.
It contains pieces of information that distinguish a living organism from another. The features of a living being are dependent on the pieces of information. Each one of us possesses a unique DNA.
Key Takeaways
- Mitochondrial DNA is found in the mitochondria, while nuclear DNA is in the cell nucleus.
- Mitochondrial DNA is inherited only from the mother, whereas nuclear DNA is inherited from both parents.
- Mitochondrial DNA has a circular shape and is smaller in size, while nuclear DNA is linear and more extensive.
Mitochondrial DNA vs Nuclear DNA
Mitochondrial DNA is the deoxyribonucleic acid (DNA) found inside the mitochondria which is a small structure that makes energy for cells found in the cytoplasm. The genome is derived entirely from the mother. Nucleus DNA is the hereditary material found in the nucleus of the cell. It provides a blueprint for the growth and development of all organisms.
Mitochondrial DNA is found inside the mitochondria along with ribosomes. Ribosomes are responsible for the production of protein.
The size of the mitochondrial DNA is 16,569 bp. The mitochondrial DNA is cellular in shape and different from the nuclear DNA.
The mitochondrial DNA is the result of an evolution that took place one and a half billion years ago. Mitochondrial DNA has the self-replicating capability.
The nuclear DNA is situated in the nucleus of the cell. It depicts a rod-like structure.
Friedrich Miescher first observed the nuclear DNA in the year 1869. Since then, a new horizon that deals with genetics has come into studies. Nuclear DNA is huge, and they are around three hundred billion letters long.
They contain all the genetic pieces of information of an individual and monitor all the functions that initiate in the human cell.
Comparison Table
| Parameters of comparison | Mitochondrial DNA | Nuclear DNA |
|---|---|---|
| Definition | DNA present inside the mitochondria is known as mitochondrial DNA. | DNA in the nucleus of the cell is called nuclear DNA. |
| Structure | It has a circular structure that does not resemble nuclear DNA. | Linear or rod-like structure. |
| Size | 16,569 bp | 3.3109bp |
| Density of gene | One per four hundred fifty bp | One per forty thousand bp |
| Per cent of coding DNA | 93% | 3% |
What is Mitochondrial DNA?
Mitochondria is the source of the energy of our cells. The number of mitochondria varies from cell to cell. In other words, cells capable of executing more energy contain more mitochondria than those requiring lesser energy to perform.
If we magnify the structure of mitochondria, we can see it consists of an outer and inner membrane. Inside the inner membrane, we find DNA as well as ribosomes.
Due to the presence of ribosomes (protein factories) and DNA within the mitochondria, it can initiate protein synthesis.
Genetic materials are present in the nucleus of the cell, while here, we find mitochondria have their DNA (genetic pieces of information). Thus mitochondria can replicate themselves.
Evolution (which took place 1.5 billion years ago) is the reason behind the presence of mitochondrial DNA (maternal DNA). The theory of endosymbiosis states that initially, mitochondria was a prokaryotic cell.
When the prokaryotic cell was engulfed by the eukaryotic cell, a symbiotic relationship was established between them. The DNA within the mitochondria is the mitochondrial DNA. The mitochondrial DNA is circular.
The mitochondrial DNA is sixteen thousand letters long. One per cent of the cellular DNA is mitochondrial DNA. Mitochondrial DNA is composed of light and heavy strands.
What is Nuclear DNA?
Our body is made up of billions of cells, an animal cell lacks a cell wall. We are eukaryotic beings.
Each cell has its nucleus, and the nucleus is the home of DNA. The DNA present in the nucleus of the cell is nuclear DNA.
Each individual has a unique set of DNA that differentiates them from other individuals. The concept of DNA was initiated in 1869 by Friedrich Miescher.
With the introduction of DNA, we were able to unfold the mysterious world of genetics.
DNA initiates and plans all the functions of the cell, and it is considered the head of the cell. The twisted ladder-shaped DNA termed as double helix implies DNA is a polymer.
So polymers are an accumulation of repeated monomers. These monomeric units are glucose molecules, and each of the glucose units is bonded via glucosidic bonds.
DNA stores all the pieces of information of an individual. It plays a pivotal role in the functioning of the cells. Living organism reflects the genetic traits of their unique DNA.
Our skin colour, the colour of our eyes, our height, and other relative features are the result of the genetic pieces of information our DNA contains. The nuclear DNA is as large as three million letters.
Main Differences Between Mitochondrial DNA and Nuclear DNA
- The mitochondrial DNA encodes only thirty-seven genes, whereas the nuclear DNA encodes twenty-thousand to thirty thousand genes.
- The mitochondrial gene is sixteen thousand letters long. The nuclear DNA is three billion letters long.
- The mitochondrial DNA does not contain histone proteins, whereas the nuclear DNA contains histone as well as non-histone proteins.
- The mitochondrial DNA depicts maternal inheritance, whereas the nuclear DNA shows mendelian inheritance and parental inheritance.
- The mitochondrial DNA is present in the mitochondria, while the nuclear DNA is situated in the nucleus of the cell.
- The gene density in the mitochondrial DNA is one to four hundred and fifty base-pair whereas gene density in nuclear DNA is one per forty thousand base pairs.
Last Updated : 11 June, 2023
I’ve put so much effort writing this blog post to provide value to you. It’ll be very helpful for me, if you consider sharing it on social media or with your friends/family. SHARING IS ♥️
Piyush Yadav has spent the past 25 years working as a physicist in the local community. He is a physicist passionate about making science more accessible to our readers. He holds a BSc in Natural Sciences and Post Graduate Diploma in Environmental Science. You can read more about him on his bio page.
The article provides a clear and comprehensive overview of the differences between mitochondrial DNA and nuclear DNA.
I found the article to be very informative as well.
Absolutely, Jwilliams. It’s thorough and well-explained.
This is a very informative article on DNA. I’ve learned a lot of new things.
I feel the same way. This was an excellent read.
The comparison table is very clear and makes it easy to understand the differences between mitochondrial DNA and nuclear DNA.
Yes, I found it quite helpful as well.
I’m not sure some of the info here is completely accurate. I’d like to see more references to peer-reviewed scientific articles.
This article has provided valid references below the post.
I agree with Sarah, there should be more references.
I think this article does a good job of explaining the evolution and differences between mitochondrial and nuclear DNA.
I couldn’t agree more, Watson.
It’s really fascinating to learn about the history of DNA.
This article lacks depth and fails to explore the topic in any meaningful way.
I appreciate the scientific detail in this article. It’s a valuable resource for learning about DNA.
I didn’t realize the differences between mitochondrial DNA and nuclear DNA were so substantial. This has been an eye-opening read.
I had the same reaction, Rob. It’s quite interesting.