Difference Between Necrosis and Apoptosis

Necrosis and Apoptosis are two different types of cell death that occur in response to certain stimuli. Both Necrosis and Apoptosis have programmed cell deaths that play an important role in many biological processes. Necrosis is caused by external sources such as trauma, infection, or toxins, while Apoptosis is a normal programmed pathway that creates space for new cells to grow and divide.

Necrosis vs Apoptosis

The main difference between Necrosis and Apoptosis is Necrosis is a harmful cellular process, but Apoptosis is a regular process. Necrosis can be caused by external agents, but Apoptosis cannot be caused by external agents. Organelles are functional in Apoptosis but not functional in Necrosis. Apoptosis is not a harmful process, but Necrosis is a damaging process.

Necrosis and Apoptosis

Necrosis is the death of working cells in living tissue in the body. Necrosis can be caused by infection, trauma, toxins, and ionizing radiation, and in some instances is an adverse side effect of cancer treatment. The resultant dead tissue has a characteristic pale-yellow color and starts to decompose. The most common symptom of Necrosis is discoloration due to a lack of oxygen or the presence of hemosiderin.

Apoptosis is a cell death that occurs in multicellular organisms for the benefit of the body. There are two types of Apoptosis: the intrinsic pathway and the extrinsic pathway. Apoptosis is essential for our survival but can be dangerous if it gets out of control. Apoptosis is the process of cell death that occurs when certain cells are prevented from dividing.

Comparison Table Between Necrosis and Apoptosis

Parameters of ComparisonNecrosisApoptosis
Caused byExternal agentsNone, metabolic reaction
OrganellesFunctionalNot functional
SymptomsTissue deathNo tissue death
Occurs due toBacterial infectionsSelf-generated signals

What is Necrosis?

Necrosis is a form of cell injury which results from the death of cells in living tissue by an unhealthy process. Necrosis can be caused by different factors, including infection, embolism, chemicals, and radiation. This typically occurs in areas where blood supply has been physically compromised, such as the fingertips or toes.

Necrosis is a condition in which a body part dies due to a lack of blood supply. Not good. Necrosis is a medical emergency, and the longer you wait to treat it, the more damage it can do. In most cases, if Necrosis isn’t treated within 2-3 days, the tissue will die and have to be removed. This is extremely painful for patients and can lead to infections if not performed by an experienced surgeon with excellent surgical skills.

Necrosis is one of the most common reasons that people will need plastic surgery. It happens when there is a break in the blood vessels, allowing blood to leak out and destroy surrounding tissue. When this occurs under the skin, it becomes apparent as a dark purple or black mark.

It can also happen inside of our bodies, where it’s called gangrene. When this happens in the intestines, it’s known as peritonitis. Gangrene and peritonitis are just different names for Necrosis.

What is Apoptosis?

Apoptosis is a natural and healthy process that occurs throughout our lives. Intrinsic Apoptosis occurs when cells kill themselves for reasons within the body, such as maintaining homeostasis or preventing cancerous growths.

Extrinsic Apoptosis occurs when something outside of the cell causes it to die on cue, such as an immune system response to infection by a virus. Apoptosis is essential for our survival but can be dangerous if it gets out of control. The mechanism by which Apoptosis is triggered was discovered in 1972 by Dr . John Foxton Ross Kerr, who termed the phenomenon “Programmed Cell Death.”

This discovery drew attention to the significance of Apoptosis in physiological development and disease, leading scientists to recognize Apoptosis as an important biological process. For many years, scientists assumed that embryonic cells were naturally resistant to apoptotic cell death due to their high undifferentiated potential.

When we are born, 100 billion cells die each minute to ensure we have the correct number for growth and development during childhood while also ensuring we don’t outgrow our skin. The process of Apoptosis, or programmed cell death, is an essential part of life. The human body contains billions of cells, and every day, millions of them die to make way for new ones.

Main Differences Between Necrosis and Apoptosis

  1. Necrosis is a cellular process, but Apoptosis is a regular process.
  2. Necrosis is caused by external agents but not Apoptosis.
  3. Organelles are functional in Necrosis but not functional in Apoptosis.
  4. Necrosis is harmful, but Apoptosis is beneficial.
  5. Necrosis has symptoms like tissue death, but Apoptosis does not have any tissue death.
  6. Necrosis occurs due to the action of bacterial infections, but Apoptosis occurs due to self-generated signals.
Difference Between Necrosis and Apoptosis


Necrosis occurs when the body is unable to repair tissue that has been damaged. Instead, the cells die and release substances that damage surrounding tissues. Necrosis can occur in any organ or tissue, but it is most common in muscle, brain, heart, kidney, liver, skin, and eyes. It can also occur in bones and cartilage.

Necrosis is the death of living cells in the tissues of the body.

Necrosis can occur when tissue dies due to a lack of oxygen or an interruption in blood supply. The purpose of this article is to explain the causes, symptoms, treatment, and prevention methods relating to Necrosis. The main focus will be on “necrotizing fasciitis,” a rare disease that has been getting attention recently because it is potentially fatal if not treated immediately.

Apoptosis, the process of programmed cell death, is a vital part of development and homeostasis. It is significant in embryogenesis and adult life. In adult life, it helps regulate both inflammatory diseases from autoimmune disorders to cancer as well as neural degeneration from stroke/parkinson’s/ALS to neurodegenerative disease.

In this review, we will cover the basic mechanisms of Apoptosis then discuss how it may be beneficial for both inflammation and neural degeneration. Apoptosis is a process of programmed cell death by which one cell kills itself for the good of the whole organism. This self-destruction occurs in multicellular organisms to ensure the proper functioning of various systems by eliminating unnecessary or damaged cells.


  1. https://go.gale.com/ps/i.do?id=GALE%7CA4015538&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00368075&p=AONE&sw=w
  2. https://www.sciencedirect.com/science/article/pii/S0002944010647797
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