Omeprazole vs Pantoprazole: Difference and Comparison

Everyone gets panicky when it comes to knowing of a major disease, and they start seeking medication by consulting professionals or on the internet.

But not many show this type of concern for chronic or small problems, which might be the reason for the serious disease.

It is important to treat any health-related problem at the correct time or on the initial days; an example of such a problem is a digestive issue or gastric problem.

They are very common and can happen to anyone; therefore, everyone should take proper care of them.

Some medications that can be taken to cure or help such problems are omeprazole and pantoprazole.

Key Takeaways

  1. Omeprazole and Pantoprazole are proton pump inhibitors for treating acid reflux and ulcers.
  2. Omeprazole has a longer half-life than Pantoprazole, meaning it stays in the body longer.
  3. Pantoprazole may be less likely to interact with other medications than Omeprazole.

Omeprazole vs Pantoprazole

Omeprazole is a drug under the Prilosec brand, and it is used to treat various diseases, including gastroesophageal reflux disease, and its treatment is from four to eight weeks. Pantoprazole is a medicine that is used for stomach-related ailments, and its treatment lasts for up to eight weeks.

Omeprazole vs Pantoprazole

Omeprazole is a medicine used for the treatment of several diseases, such as gastroesophageal disease, etc. This is sold under the brand name Prilosec among others.

The standard dosage of this medicine is 20 mg once daily and can be taken for 4 to 8 weeks depending upon the treatment and guidance of the doctor. They can be easily affordable and used by children above a year old.

Pantoprazole is also a medicine used for treating several stomach-related diseases. This is sold under the brand Protonix among others. This can be used for short-term treatment, for example, 8 weeks only.

The standard dosage of this medicine is 40 mg once daily. It is quite expensive than other available medicines and can be consumed by everyone above 5 years old.

Comparison Table

Parameters of ComparisonOmeprazolePantoprazole
Generic nameOmeprazolePantoprazole
Standard dosage20 mg40 mg
Treatment duration4 to 8 weeksUp to 8 weeks
Used byChildren 1 year and olderChildren 5 year and older

What is Omeprazole?

It is mainly used for decreasing the acid produced in the stomach. Following is some information about Omeprazole:

  • Molar mass: 345.4 g/mol
  • CAS ID: 73590-58-6
  • Formula: C17H19N3O3S
  • Boiling point: 600 °C
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  1. Treat gastroesophageal reflux disease (GERD) 
  2. Promote healing of damage caused by stomach acid to the esophagus.
  3. Treating gastric ulcer.
  4. Control heartburn.

Following are some precautions that must be taken before consuming omeprazole:

It should be avoided if you are allergic to:

  • If you are allergic to any similar medicine.
  • Have breathing problems or any kidney-related problems.
  • You are on HIV medication.

You have to seek professional help in case of the following:

  • A problem in swallowing.
  • Vomit that looks like blood or blood stooling.
  • Heartburn
  • Frequent chest pain.
  • Liver disease.

In general also, if you are facing any issue or difference from the routine, you should consult a professional before intaking the medicine.

Side Effects:

  • It can cause extreme stomach aches and bloody stools that may be watery.
  • Unusual pain in the hip, back, or any other part of the body.
  • It can also cause a seizure.
  • In some cases, it can also cause some serious kidney-related problems.
  • Lupus.
  • Cause low magnesium.

What is Pantoprazole?

It is for the treatment of most of the stomach-related problems caused by acid production. Following is some information about Pantoprazole:

  • Molar mass: 383.371 g/mol
  • CAS ID: 102625-70-7
  • Boiling point: 586.9°C


  1. Use for the treatment of gastroesophageal reflux disease (GERD) or any related problem. 
  2. For the treatment of Zollinger-Ellison syndrome.
  3. Any other condition that involves stomach acid.

Precautions that should be taken:

  • It should be avoided if you are taking any of these medicines edurant, complete, juluca, odefsey.
  • If you have any other disease, such as breathing or kidney related.
  • If you have experienced an allergic reaction to similar medicines.
  • Other problems that may include pain or vomiting should also be told to the doctor before consumption.

The dosage of this medicine depends upon the age of the person, which should be prescribed by children; otherwise, the standard dosage mentioned on the packaging should be taken by children above 5 years and all adults.

These medicines might have some side effects, too, which can be pain, vomiting, kidney problem, etc.

In case of any minor problem, it can be ignored or stopped by not consuming the medicine any further, but if some major side effects must be checked by the professionals immediately.


Main Differences Between Omeprazole and Pantoprazole

  1. Both Omeprazole and Pantoprazole are sold under different brand names, but mainly the brand name under which the omeprazole is sold is Prilosec, whereas Pantoprazole is sold under the brand name Protonix.
  2. Both of them are different when it comes to daily dosage. Omeprazole’s dosage is less in comparison, which is 20 mg once a day, whereas in the case of Pantoprazole daily dosage is relatively high, which is 40 mg once a day.
  3. They also differ in terms of their treatment duration; Omeprazole can be used only for a duration of 4 weeks minimum and a maximum of 8 weeks, while with Pantoprazole, it takes 8 weeks at least for complete treatment.
  4. Omeprazole can also be consumed by children below the age of 5 years but above 1 year, but Pantoprazole cannot be recommended for consumption by children below 5 years old. Although both of them can be consumed by adults.
  5. In terms of affordability, Omeprazole can be easily affordable as it is not very much expensive or less expensive when compared to Pantoprazole which is relatively more expensive.
  6. Lastly, they also have different side effects. For example, cough and back pain could be among many side effects caused by Omeprazole, while they are not caused by the consumption of Pantoprazole. Also, omeprazole can cause acid regurgitation, which is also not caused by Pantoprazole.
Difference Between Omeprazole and Pantoprazole
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Last Updated : 17 August, 2023

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