Difference Between Neosporin and Polysporin

Antibiotic development is usually recognized as one of the most glorious accomplishments in the realm of health research.

Deaths caused by bacterial complications have been progressively decreasing in the years after the first antibiotic was discovered.

Scientists and researchers are constantly on the lookout for better, safer medicines.

Hence this article, the differences between two leading antibiotic medicines Neosporin and Polysporin.

This article will highlight all the features, aspects, and differences between both medicines.

Neosporin vs  Polysporin

The main difference between Neosporin and Polysporin is that Neosporin has three active compounds: Neomycin, myxin B, and Bacitracin, whereas polysporin has only two: Polymyxin B and Bacitracin. Scientists and researchers are constantly on the lookout for better, safer medicines. With this encouraging news about the fight against bacteria, we are gradually becoming conscious of the importance of antibiotics in human existence.

Neosporin vs Polysporin

Neosporin is a drug used to avoid and cure minor skin infections caused by minor wounds, scratches, or blisters. It is accessible for self-medication without even a certification or prescription.

This item should not be applied to large portions of the body.

When using this product for severe skin wounds or infections like burning cases or surgeries, a doctor’s guidance is always recommended.

These sorts of diseases may necessitate a different therapy. This medicine comprises the antibiotics neomycin, bacitracin, and polymyxin, which function by inhibiting bacterial growth.

This drug solely prevents and cures bacterial skin infections.

This drug is used for the treatment of skin problems. This medicine comprises the antibiotics neomycin as well as polymyxin, which function by inhibiting bacterial growth.

It also includes hydrocortisone, a corticosteroid that acts to reduce swelling and irritation. This drug is solely used to control bacterial skin infections and it acts swiftly on burning wounds too.

Comparison Table Between Neosporin and Polysporin

Parameters of ComparisonNeosporinPolysporin
ConstituentsNeomycin, Polymyxin B, and Bacitracin. There are many anti-inflammatory agents as well to soothe the pain and inflammation on the skin.Polysporin has only two: Polymyxin B and Bacitracin. Antibacterial ointment that aids in the prevention of skin problems.
FormsOintment, cream and foam. Some companies also sell the spray form of neosporin.Ointment and cream only.
Speed of HealingFaster than polysporin. It is available over-the-counter.It is a slow medicine however, it justifies its low-cost and durability.
Ideal ForSkin bruises, cuts and wounds.Burning cases, heavy usage would not cause irritation however, a doctor’s advice is recommended.
DownsidesNot recommended for burnt skin or very deep cuts.Skin rashes on sensitive skins can occur. It is not good for bug-bites.

What is Neosporin?

Neosporin Ointment is a dermatological drug that’s also classified as an “antibiotic” and is mainly used to treat common skin problems.

Neosporin Cream is a first-aid antibacterial medication used to avoid infection in small skin wounds, scratches, or wounds.

Neosporin Ointment eye compositions successfully treat infectious diseases of the outward part of the eye, including conjunctivitis (inflammatory condition of the eye’s mucosal surface (conjunctiva), corneal scarring (inflammatory response of the cornea due to some injury), keratoconjunctivitis (irritation of the conjunctiva as well as cornea), blepharitis (irritation on the inner part of the eyelids), and blepharoconjunctivitis.

Staph infection happens when dangerous bacteria multiply in the body and can cause sickness.

Neosporin comes in a range of compositions. One of the most popular types of Neosporin includes three medications and is also known as “triple-antibacterial ointment”.

It includes bacitracin, polymyxin B, as well as neomycin and comes in a variety of trademark and inexpensive ointments, sprays, creams, and foams.

Neosporin has also been marketed as Neosporin + Pain Reliever Ointment which is loaded with anti-inflammatory substances like mint and Neosporin + Pain Ache Scar Ointment, which include the three medications as well as pramoxine, a topical anesthetic.

What is Polysporin?

Polysporin is a topical microbiological drug that operates in the same way as Neosporin. As a result, it serves to maintain gaping sores from becoming infected and accelerates wound healing.

The only difference is in the active chemicals utilized. It comprises Bacitracin as well as Polymyxin B. It is used as a substitute for persons who are allergic to neomycin.

This medicine is used to treat acute microbial skin infections and to lower the risk of infection after minor skin injuries. There are two antibiotics in it: polymyxin B, and bacitracin.

It is solely for external usage and should not be consumed since it causes renal harm.

Polysporin (bacitracin and polymyxin) is accessible both over-the-counter and as a pharmaceutically prescribed medicine.

It aids in the prevention of skin problems in minor wounds, scratches, or burn injuries. It is simple to use and has few adverse effects.

This lotion is intended for small injuries that are not difficult, such as minor burns, scratches, and cuts. Neither treatment is powerful enough to treat a severe skin disease or a systemic illness.

Deep wounds may need further care, such as sutures, oral antibiotics, or immunizations against illnesses like tetanus.

Main Differences Between Neosporin and Polysporin

  1. Neosporin contains neomycin whereas polysporin is a deficit of neomycin.
  2. Neosporin can cause allergies hence, polysporin is used instead as it is not allergic in nature.
  3. Neosporin is costlier than polysporin.
  4. Neosporin acts and heals faster than polysporin antibiotic ointment.
  5. Neosporin is available in foam texture whereas polysporin is only available as a topical ointment.


Polysporin and Neosporin are medicines that are suitable for treating small skin wounds in the majority of people. A few major distinctions may help you decide between the two.

Neomycin, a component of Neosporin, has been related to an increased risk of immune reactions.

Nonetheless, any of the chemicals in these products have the potential to produce an allergic response.

Both Neosporin and Bacitracin inhibit bacterial development, however, Neosporin has the added capability of killing existing germs.

Neosporin has the ability to cure more kinds of bacteria than Bacitracin, and that it’s scientifically more efficient than polysporin.


  1. https://www.rxlist.com/fdb/drugs/633/polysporin-brand.htm
  2. https://www.webmd.com/drugs/2/drug-15796/polysporin-topical/details
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