Difference Between Glipizide and Metformin

Type 2 diabetes is a chronic disease affecting the body’s blood sugar level working. It is a widespread disease with symptoms like frequent urination, fatigue, blurred vision, increased thirst and hunger, etc. There are even cases when the patient doesn’t feel the symptoms at all. Glipizide and Metformin are type-2 diabetes treating drugs.

Glipizide vs Metformin

The main difference between Glipizide and Metformin is that Glipizide is helpful in treating type-2 diabetes in adults, whereas Metformin is helpful in treating type-2 diabetes in adults and children who are above the age of 10. The working of Glipizide and Metformin differs a lot in many ways.

Glipizide and Metformin

Glipizide is a short-acting and rapid drug that is to be taken orally. It is used for the treatment of type-2 diabetes in adults and is a drug that belongs to the sulfonylureas group. It helps in lowering the blood sugar level and increasing the efficiency to use insulin. It does not help treat type-1 diabetes.

Metformin belongs to the biguanides class of drugs. It is proven to be effective in treating type-2 diabetes in adults and in children who are older than the age of 10 by decreasing the measure of glucose that a person absorbs from food and that made by the liver.

Comparison Table Between Glipizide and Metformin 

Parameters of ComparisonGlipizideMetformin
TreatsGlipizide is effective in the treatment of type-2 diabetesMetformin is useful in treating type-2 diabetes, and a small subset of it can treat type-1 diabetes too.
Class of DrugGlipizide’s class of drug is sulfonylureas.Metformin’s class of drug is biguanides.
DoseGlipizide is taken in amounts of 5mg once a day.Metformin is taken in amounts of 500mg twice a day.
FunctionIt helps in the production of insulin in the pancreas by lowering the blood sugar level.It controls the glucose amount in blood by decreasing our glucose absorption from food and our liver.
Side effectsRashes, blisters, dizziness, and hives are some common side effects of Glipizide.Cramps, vomiting, diarrhoea, nausea, headache, muscle pain, etc., are some common side effects of Metformin.

What is Glipizide?

Glipizide is an oral drug that is efficient in treating type 2 diabetes. It is mainly used for treatment in adults and is not efficient for children. Glipizide is a drug that is a member of the sulphonylureas class of drugs. It causes the production of insulin in the pancreas to help the body use insulin and ultimately lowers the blood sugar level. 

Glipizide does not help treat type 1 diabetes. Its dosage is 5 mg, to be taken once a day. Diabetes is not a disease that can be cured just by medication. Therefore alongside the treatment with Glipizide, the patient must also keep a check on their eating habits and activeness by including healthy food items in their diet and increasing exercise. A healthy lifestyle is a vital aspect of treating diabetes. 

As much as glipizide is helpful in the treatment of diabetes, it might also cause some side effects. Rashes, hives, blisters, redness and itching of the skin, light coloured stools, sore throat, and random bleeding or bruising can be some of the prominent side effects of the drug.

What is Metformin?

Metformin is the most popular drug among doctors for the treatment of type 2 diabetes. It is such a versatile drug that, apart from treating adults with type 2 diabetes, it is also valuable for treating the condition in kids over the age of 10. A subset of metformin can also be used for the treatment of type 1 diabetes. It comes from the biguanides class of drugs.

Metformin works by controlling the glucose amount in blood by lowering the patient’s glucose absorption from their food as well as from the liver. Also, it is the best antidiabetic drug to promote weight loss and reduce the condition of cardiovascular complications. The suggested dose of metformin is 500mg, taken twice daily.

But apart from its advantages, it also has several side effects. Gastrointestinal problems, muscle pain, nausea, vomiting, headaches, nail changes, heat burn, etc., are some of the most common side effects of metformin. In the end, metformin is just part of medication, and the patient must also simultaneously look after their diet and exercise.

Main Differences Between Glipizide and Metformin

  1. Glipizide is helpful in treating type-2 diabetes, whereas Metformin is useful in treating type-2 and type-1 diabetes.
  2. Glipizide helps in producing insulin in the person’s pancreas by lowering the blood sugar level. Metformin effectively controls the glucose amount in the blood by checking the glucose absorption from the liver and food.
  3. Glipizide is a member of the Sulphonylureas class of drug, while Metformin is a member of Biguanides.
  4. Glipizide is taken as a dose of 5mg once a day. On the other hand, Metformin is taken as a dose of 500mg twice a day.
  5.  Side effects of Glipizide can be blisters, dizziness, headaches, rashes, hives, etc., while Metformin’s side effects include digestive problems, cramps, nausea, vomiting, fever, etc.

Conclusion

Type 2 diabetes is a widespread illness among people of all age groups but especially older adults. It is vital to go for regular checkups to keep a check on blood sugar levels, and in any case, if they are alarming, the person must go for treatment immediately. Glipizide and metformin are two essential and valuable drugs that can be used for the efficient treatment of type 2 diabetes. They are similar because they are antidiabetic and are taken orally, but they also have a lot of differences. A 5 mg dose of Glipizide is taken once a day, whereas a 500 mg dose of metformin is taken twice a day. Apart from all the medication, it is crucial to enhance your lifestyle by keeping a check on eating habits and including exercise in the daily schedule.

References

  1. https://care.diabetesjournals.org/content/36/5/1304.short
  2. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1742-1241.2010.02510.x
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