Difference Between Lorazepam and Diazepam

Lorazepam and diazepam are generic medications used to address anxiety disorders as well as other psychological healthcare issues. Both medications are benzodiazepines. They function by boosting GABA, or gamma-aminobutyric acid, action in the brain. Owing to the Drug Enforcement Administration, both lorazepam and diazepam are Schedule IV substances (DEA). This implies that, like other benzodiazepines, these medications entail the risk of dependency and misuse.

Lorazepam vs Diazepam

The main difference between Lorazepam and Diazepam is that Diazepam lasts lengthier and much longer in the system than Lorazepam. Ativan’s general term, Lorazepam, has a half-life of approximately 18 hours. Diazepam, the generic version for Valium, on the other side, has a half-life of up to 2 days. Lorazepam is an intermediate-acting Benzodiazepine, whereas Diazepam is a long-acting Benzodiazepine.

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Lorazepam is a benzodiazepine medication that is marketed under the brand names Ativan and others. It is employed to manage anxiety problems, insomnia, acute restlessness, severe convulsions, alcohol withdrawals, and chemotherapy-induced sickness and nausea. It is often used throughout the surgical intervention to disrupt recollection consolidation and to calm patients who are being continuously evacuated.

Diazepam is a benzodiazepine medication that functions as an anxiolytic. It is often used to manage depression, convulsions, alcohol withdrawal conditions, benzodiazepine withdrawal disorder, muscular spasms, sleeplessness, and troubled legs disorder. It might potentially be used to produce loss of memory during surgical treatments. It can be taken orally, injected into the rectum, shot into muscles, pumped into an artery, or sprayed into the nose.

Comparison Table Between Lorazepam and Diazepam

Parameters of ComparisonLorazepamDiazepam
EffectsLorazepam acts instantly and consists of a half-life which is approximately up to 18 hours.Diazepam takes time in acting and consists of a half-life which is approximately up to 48 hours.
DigestionLorazepam is digested by a process called glucuronidation in the liver.Diazepam is digested by cytochrome enzymes in the liver.
EffectivenessLorazepam was seen to have worked faster and better for patients with terrible symptoms initially.Diazepam was seen to have slower for patients with terrible symptoms initially.
CostLorazepam is a bit on the costlier side.Diazepam is a bit on the cheaper side.
Brand nameThe brand name of Lorazepam is known as Ativan.The brand name of Diazepam is known as Valium

What is Lorazepam?

Anxiety is treated using this drug. Lorazepam belongs to the benzodiazepine class of medications, which work on the brain and nerves (central nervous system) to provide a calming effect. This medication works by boosting the effects of a natural substance in the body (GABA).

As instructed by your doctor, take this medicine by mouth with or without food. The dose is determined by your medical condition, age, and treatment response. To get the most out of this medicine, take it on a regular basis as advised by your doctor. Apply it at the same time(s) every day to help you recall.

Despite the fact that it benefits many people, this medicine can occasionally lead to addiction. If you have a substance use issue (such as overuse or addiction to drugs/alcohol), your risk may be increased. To reduce the danger of addiction, take this medicine precisely as directed.

Do not abruptly discontinue the use of this medication without first visiting your doctor. When this medication is abruptly discontinued, several symptoms may worsen. It is possible that your dose will need to be progressively reduced. When this drug is used for an extended period of time, it may lose its effectiveness. Consult your doctor if this drug is no longer working properly.

What is Diazepam?

Diazepam is a medication used to treat anxiety and agitation induced by alcohol withdrawal. It’s also used in conjunction with other drugs to treat muscular spasms and stiffness associated with health illnesses such as cerebral palsy, paraplegia, athetosis, and stiff-man disease. Diazepam is frequently used in conjunction with other drugs to treat seizures. Diazepam belongs to the benzodiazepine class of medicines. It helps by relaxing aberrant brain overactivity.

Diazepam is available as a pill, a solution, and a concentrate (liquid) for oral administration. It is often taken 1 to 4 times a day, with or without food. Observe the instructions on your medication label exactly, and ask your doctor or pharmacist to clarify any parts you don’t understand. Diazepam should be taken exactly as prescribed.

Diazepam has the potential to become addictive. Do not take a higher dose, take it more frequently, or for a longer period than your doctor has prescribed. Inform your doctor if you have ever consumed excessive quantities of alcohol, if you use or have ever used street drugs, or if you have abused prescription prescriptions. During your therapy, do not consume alcohol or use illegal substances.

If you have any of the following symptoms, contact your doctor or seek emergency medical attention right away: extraordinary dizziness, lightheadedness, excessive drowsiness, delayed or trouble breathing, or lack of responsiveness.

Main Differneces Between Lorazepam and Diazepam

  1. The primary distinction between Lorazepam and Diazepam is that Lorazepam exits the body more rapidly, minimizing the possibility of toxicity or adverse effects.
  2. Lorazepam also has fewer negative interactions with other drugs than Diazepam as Diazepam can cause harmful reactions if mixed with other drugs.
  3. Lorazepam is more efficient than Diazepam in preventing the onset of ketamine-related comorbidities.
  4. The price of Lorazepam is much more than the price of Diazepam.
  5. Lorazepam can elicit extrapyramidal signs, which are characterized by a range of drug-induced spontaneous muscle motions, and Diazepam can cause neutropenia, which is characterized by a hazardous decrease in the body’s number of white blood cells.

Conclusion

The medications Lorazepam and Diazepam are classified as Schedule IV. Those who have a history of alcohol or drug misuse may be at a higher risk of Benzodiazepine dependency and abuse. Dependency and misuse may raise the risk of Benzodiazepine death. Extreme loss of control, critically reduced blood circulation, respiratory distress, and coma is among the indications and consequences of Benzodiazepine abuse. 

Use just the lowest effective dose of lorazepam or diazepam. Other potential cautions and restrictions should be discussed with a physician or healthcare practitioner. Both Lorazepam and Diazepam are useful medications. It is not advisable to combine alcohol with benzodiazepines. Liquor and Benzodiazepines both have the potential to create CNS adverse effects such as sleepiness and disorientation.

References

  1. https://www.sciencedirect.com/science/article/pii/S0007091217449531
  2. https://www.sciencedirect.com/science/article/pii/S0007091217453153
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