Difference Between Excedrin and Excedrin Migraine

If the person is already suffering, then pain can be troublesome if it originated from different conditions. The pain is quite disturbing when it comes to several occasions.


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Determination of a person’s health status is important as it is the fifth vital sign, and pain can tell that.  

With the help of exceeding medical conditions, now it is easy to treat and realize the pain. The medicines are consist of painkillers and other relief meds. Excedrin and Excedrin migraine are two of the painkillers. 

Excedrin vs Excedrin Migraine 

The difference between Excedrin and Excedrin migraine is that Excedrin is a drug given for facing aches like toothache, menstrual aches, muscle aches, etc. On the other hand, Excedrin migraine is also a drug given while facing unbearable and severe head pain.  

Excedrin vs Excedrin Migraine

Excedrin is a pain reliever medicine and is consumed while suffering mild aches. It is preferred when a person is having aches like toothache, headache, sinusitis, menstrual aches or cramps, muscle pain, etc.

It is generally available in the nearby medical store.  

Excedrin migraine is also a drug that is a combination of typically three different types of drugs (acetaminophen, caffeine, and aspirin). 

These drugs generally give relief to migraine-caused pain. It comes in the form of a coated oral medicinal tablet. 

Comparison Table

Parameters of ComparisonExcedrinExcedrin Migraine
InterpretationIt is a drug used to treat minor painIt is used to treat head severe pain or any migraine pain
IntroducedIn the year of 1960In the year of 1998
DosagePrescribed by the doctor or directed on the labelOnly two doses in 24 hours
AvailabilityIn varieties of formIn three different forms
ReliefGiven while facing aches like toothache, menstrual aches, muscle aches, etc.Given while facing unbearable and severe head pain

What is Excedrin? 

Excedrin is generally a combination of caffeine, aspirin, and acetaminophen. Caffeine works as a stimulant of the central nervous system.

Aspirin reduces substances in the body that causes fever and pain. At last, acetaminophen is a fever reducer and pain reliever.  

Excedrin is used to treat aches caused by muscle aches, arthritis, common cold, tension headaches, menstrual cramps, toothaches, nasal condition, and many more.

Aspirin can cause a condition of Reye’s syndrome, and that’s why a teenager or child should not consume with flu symptoms, chickenpox, and fever.  

Excedrin might not be on a dosing schedule, in contrast, to be used when needed. As soon as you remember the missed dose, then take it right away if you are on schedule.

Do not mix up extra medicine if it is almost time for the next scheduled dose. 

There is no need to consume Excedrin than its recommendation. Because an overdose of acetaminophen can lead to liver damage and even cause death.

If issues like itching, jaundice, and loss of appetite occur in the patient then it becomes necessary to consult a doctor. 

What is Excedrin Migraine? 

Excedrin migraine is a relief medication for over-the-counter pain. It is generally used to treat pain caused by migraine headaches.

For any person older than 18 years, two caplets are the maximum dosage in any 24 hours.  

When the body is becomes used to the medication, then some effects might go away. If any of the common side effects do not go away or causes problems then it is necessary to call the doctor.

The common side effects consist of nervousness, rapid heartbeat, and sleep in trouble.  

Drug interactions might cause when patients take the medication in an addition to Excedrin migraine. It can lead to a decrease or increase in the effect of Excedrin migraine or any other medications.

There are also chances of a high risk of side effects.  

For most people, Excedrin migraine is safe to consume, but still, it is necessary to be careful. Excedrin migraine makes the conditions like liver disease, high blood pressure, asthma, kidney disease, etc. worse. 

Main Differences Between Excedrin and Excedrin Migraine  

  1. Child or teenager should not consume Excedrin if suffering from chickenpox, fever, or flu symptoms and also if allergic to acetaminophen, caffeine, any NSAID, etc., while Excedrin migraine should not be given to who had a recent viral infection.  
  2. When it comes to side effects, Excedrin side effects include sleep problems, upset stomach, and heartburn. On the flip side, side effects of Excedrin migraine are nausea, vomiting, and headache.  
  3. If someone has an overdose of Excedrin then it can be easy to figure out the symptoms like sweating, stomach pain, and diarrhea. But overdose symptoms of Excedrin migraine include weakness, whites of eyes, and dark urine.  
  4. Drinking alcohol, cola, and energy drinks should be avoided with the intake of Excedrin. On the other hand, intake of caffeine sources like coffee as well as alcohol should be avoided with Excedrin migraine.
  5. If the patient intake Excedrin and suffering from asthma, kidney disease it is essential to consult a doctor, and stomach ulcer, while liver disease, blood clotting disorder, and intestinal bleeding are conditions for Excedrin migraine. 


  1. https://headachejournal.onlinelibrary.wiley.com/doi/abs/10.1111/j.1526-4610.2004.04049.x
  2. https://web.stevens.edu/wit/research/samples/plipsy_organic_chemistry_lab_report.pdf
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