Humalog vs Novolog: Difference and Comparison

Humalog and Novolog are two rapid-acting insulins to control blood sugar in those with diabetes. Both drugs are highly effective in lowering blood glucose levels.

Key Takeaways

  1. Humalog and Novolog are rapid-acting insulin medications used to manage blood sugar in people with diabetes.
  2. Humalog begins to work within 15 minutes, while Novolog takes effect in 10-20 minutes.
  3. The duration of action for both medications is similar, ranging from 3 to 5 hours, with individual variations.

Humalog vs Novolog

Humalog is a type of insulin lispro that is rapid-acting. It is designed to start working within 10-15 minutes after injection and peak within 30-90 minutes. The effects of Humalog last for about 3-5 hours. Novolog is a type of insulin aspart that is also rapid-acting. It is designed to start working within 10-20 minutes after injection and peak within 1-3 hours.

Humalog vs Novolog

It is an FDA (Food and Drug Administration) approved drug to treat Type 1 diabetes in adults and children aged 3 years old and older, Type 2 diabetes in adults.

This medication has been approved for use in children as young as two years old. It aids in the management of blood sugar levels in persons with Type 1 and Type 2 diabetes.

Comparison Table

 Parameters of ComparisonHumalog  Novolog  
Generic nameInsulin lispro injection  Insulin aspart injection  
Age restrictionsAdults with Type 1 and 2 diabetes, as well as children aged 3 years and above with Type 1 diabetes.Adults with Type 1 and 2 diabetes, and children aged 2 years with Type 1 diabetes.   
Rapidity of action  Humalog is slower in action than Novolog.     Novolog is slightly faster in action. Takes action within 5 -10 minutes.   
Common side effects    Headache, nausea, sore throat or pharyngitis, runny nose, stomach aches, diarrhea, and muscle weakness are the common side effects of Humalog.   Headache, diarrhea, nausea, stomach ache, chest pain, and sensory disturbance.     
CostHumalog is slightly cheaper than Novolog.   Novolog is costly.     

What is Humalog? 

Humalog is an effective drug in controlling blood sugar levels. Humalog contains insulin lispro. Humalog has been approved by the Food and Drug Administration to help persons with Type 1 and Type 2 diabetes regulate their blood sugar levels.

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Humalog is safe to use in people of all ages. Humalog Mix is also premixed insulin that acts more rapidly and also has a long-lasting effect.

Each vial of Humalog contains 3 or 10 millilitres of the medication. 50 percent insulin lispro protamine and 50 percent insulin lispro are included in the Humalog mix.

Humalog is a brand-name drug. Medication of Humalog can also cause mild side effects such as headache, diarrhoea, sore throat, stomach ache, muscle weakness, etc.


What is Novolog? 

Novolog is fast-acting mealtime insulin that helps to keep blood sugar levels in check after a meal. Insulin Aspart injection is the generic name for Novolog.

Novolog is a rapid-acting insulin that takes 5 to 10 minutes to take effect. Adults with Type 2 diabetes and children aged 2 and up with Type 1 diabetes will find it very useful in controlling their blood sugar levels.

The effect of the drug can be felt for up to 2 to 4 hours. Most importantly, to avoid the risk of hypoglycemia, one should intake food a few minutes later after taking the dose. 

There are some common side effects along with serious side effects. Patients can face headaches, stomach aches, diarrhoea, chest pain, and sensory disturbance.


Main Differences Between Humalog and Novolog

  1. Humalog can be used for the treatment of 3 years old children. On the other hand, children of 2 years old can take Novolog doses for the treatment. 
  2. The market price of Humalog is lower than the price of Novolog.
Difference Between Humalog and Novolog

Last Updated : 13 August, 2023

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22 thoughts on “Humalog vs Novolog: Difference and Comparison”

  1. Both are fast-acting insulins designed to help people with diabetes. Both are approved by the FDA and can be used in both types of diabetes. They are useful for those who need a fast-acting medication to control blood sugar levels.

  2. The comparison between Humalog and Novolog is well-detailed, including their usage, effects, and side effects. This information is beneficial for those considering these medications for diabetes management.

    • I couldn’t agree more, Carmen. The article covers all the essential aspects of both drugs, making it easier for individuals to understand their differences.

    • Agreed, Ella. The comparison table helps in understanding the different attributes of the two medications. It’s important for users to know the differences.

  3. The article gives a detailed explanation of both drugs, including their names, rapidity of action, common side effects, and cost. This comparison helps in making an informed decision about which drug to use.

  4. Being aware of the common and serious side effects of both drugs is crucial for users. It’s also important to know the rapidity of action and other parameters of comparison mentioned in the table.

    • Absolutely, Aallen. The article provides important information for those who require these medications. It’s essential to consider all aspects before using them.

  5. The detailed information provided about Humalog and Novolog helps in understanding their applications and differences. Individuals can make informed choices based on the comparisons outlined in the article.

    • I agree, Pauline Wright. The article delivers valuable insights into both drugs, which are essential for individuals living with diabetes.

  6. This article provides an insightful comparison of Humalog and Novolog, including their efficacy, side effects, and costs. It’s a must-read for anyone considering these medications for diabetes control.

  7. The article contains a well-structured comparison between Humalog and Novolog, covering various parameters such as rapidity of action, common side effects, and costs. This information is very helpful for individuals who need to manage their diabetes effectively.

    • Absolutely, Leanne67. The content provides a comprehensive understanding of the differences between Humalog and Novolog, aiding individuals in making suitable choices for their diabetes management.

    • I couldn’t agree more, Leanne67. It’s crucial for individuals to have detailed insights into these medications, and the article serves that purpose effectively.

  8. The comparison table outlining the differences between Humalog and Novolog is very helpful. It’s essential to understand the variations in rapidity of action and common side effects for both drugs.

    • I completely agree, Krussell. The article has presented a detailed overview of both medications, making it easier for individuals to make informed decisions.

    • Absolutely, Krussell. The comprehensive details of Humalog and Novolog are beneficial for individuals who need to manage their blood sugar levels.

  9. The key takeaways provided in the article are vital. They highlight the main differences between Humalog and Novolog, and the comparison table helps in understanding their attributes.

    • Absolutely, Mwatson. The article is very informative and useful for individuals who are prescribed either of these medications for diabetes management.


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