Difference Between Phentermine and Phentramine

In this modern world of technology, the medical field has taken leaps, if not attained summits. Still, obesity and being overweight cause millions of death across the world. Around 340 million are obese worldwide. 


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A shocking fact is that obesity or being overweight is linked to more deaths than being underweight! More people die because they eat too much than those who don’t get enough, do not think about that.

Phentermine and phentramine are two appetite-reducing drugs that are used to deal with obesity on a short term basis.

Phentermine vs Phentramine

The difference between phentermine and phentramine is that phentermine is a prescription drug. On the other hand, phentramine is a pharmaceutical drug, you do not need a prescription to buy.

Phentermine vs Phentramine

Comparison Table

Parameter of ComparisonPhenterminePhentramine
Type of drugPrescription drugPharmaceutical grade drug
What is it used forDealing with obesityDealing with obesity
Active IngredientsPhentermine Hydrochloride (HCL)Phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous) 
Inhibiting actionAppetite suppressingAppetite supressing
Available without prescriptionNoYes
AddictiveNoMaybe (not proven)

What is Phentermine?

Phentermine is a short-term weight loss drug, and it is approved by the Food and Drug Administration (FDA) of the United States of America.

It is used for the treatment of excessively obese patients, along with making the transition to healthy lifestyle choices such as proper exercise and a nutritious diet.  It can also be called an appetite suppressing drug.

It is supposed to reduce the appetite of an individual, and it does so by affecting the central nervous system. The active ingredient in phentermine is Phentermine Hydrochloride (HCL)

It works by stimulating the hypothalamus gland, and the affected neurotransmitters. Neurotransmitters are chemicals present in the brain through which the brain cells communicate with other cells.

The hypothalamus gland of the brain controls the body temperature, sleep cycles, and appetite of a person, thus when phentermine is taken it stimulates the gland and reduces one’s appetite.

Studies have shown that phentermine has been effective, at least in placebo-controlled trials.  The bottom line is that Phentermine is a drug, and it should be the last option for an obese-person. 

If the situation is very bad and they can’t go on without immediate intervention, phentermine might be prescribed to them by their doctor.  Phentermine cannot be bought at medical stores without a prescription, and one should not try to take it without a prescription.

Side effects of phentermine include insomnia, depression, anxiety, swelling in the legs, chest pain, increased blood pressure, headaches, and others. 


What is Phentramine?

Phentramine is a pharmaceutical drug, graded at the pharmaceutical level. It does not need to be prescribed and it supposedly has natural ingredients. Phentramine works by suppressing one’s appetite, increasing the energy levels, giving the calorie burning procedure a boost.

It also helps keep one’s blood sugar levels in check. Phentramine can be taken by those wanting to reduce weight and live a healthier life. People using phentramine may be suffering from obesity or may be overweight.

Obesity and overweight are related to cardiovascular diseases, breathing problems, and even diabetes. Phentramine acts as a drug that helps with weight loss. It is sold by pharmaceutical companies as a dietary supplement. You can buy bottles of 30-60 pills.

The active ingredients in Phentramine are Phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous).

It works on similar lines to Phentermine but it has different ingredients. These ingredients are capable of increasing metabolism and favoring thermogenesis. Thermogenesis is the process of heat-producing by the body, a way to release energy, and thus to reduce weight.

Even though Phentramine is not a prescription pill, it is advised to check with your doctor before you start taking it. If you have any previous conditions, it is best to go to your doctor so that he/she can clear contradictions if any.

Phentramine might also have possible effects such as insomnia, anxiety, vertigo, shaking, headaches, nausea and vomiting, frequent urination, tinnitus, and others. No study has proven these side-effects though, they are theoretical. 


Main Differences Between Phentermine and Phentramine

  1. Phentermine is an FDA approved drug. On the other hand, Phentramine is a pharmaceutical drug.
  2. Phentermine is a prescription drug, you cannot buy it without a doctor’s permission. On the other hand, Phentramine is a pharmaceutical-grade drug, you can buy it without a doctor’s prescription.
  3. Phentermine has only one ingredient, Phentermine Hydrochloride (HCL). On the other hand, Phentramine has an array of active ingredients, namely phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous)
  4. Phentermine is been proven effective to have a positive effect on patients. On the other hand, no studies have proven the effectiveness of Phentramine, although it is claimed to have similar effects as Phentermine.
  5. Phentermine works by stimulating the hypothalamus gland of the brain, a gland that is responsible for body temperature, sleep, and the appetite of a person. On the other hand, Phentramine works by boosting the metabolism rate and boosting thermogenesis in a person’s body.
  6. Phentermine is not addictive. On the other hand, Phentramine might be addictive.


  1. https://onlinelibrary.wiley.com/doi/full/10.1002/oby.20584
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