Phentermine vs Phentramine: Difference and Comparison

In this modern world of technology, the medical field has taken leaps, if not attained summits. Still, obesity and being overweight cause millions of death across the world. Around 340 million are obese worldwide. 

A shocking fact is that obesity or being overweight is linked to more deaths than underweight! More people die because they eat too much than those who don’t get enough, do not think about that.

Phentermine and phentramine are two appetite-reducing drugs that are used to deal with obesity on a short-term basis.

Key Takeaways

  1. Phentermine and Phentramine are both appetite suppressants used to treat obesity, but they have different chemical compositions.
  2. While Phentermine is a prescription drug, Phentermine is available over the counter and is marketed as a natural alternative to Phentermine.
  3. Phentramine may be less effective than Phentermine in reducing weight and have more side effects.

Phentermine vs Phentramine

Phentermine is a prescription medication approved by the US Food and Drug Administration (FDA) for short-term weight loss treatment. It is a sympathomimetic amine that works by suppressing appetite and increasing metabolism. Phentramine is an over-the-counter weight loss supplement marketed as a natural alternative to prescription weight loss medications like Phentermine.

Phentermine vs Phentramine

Comparison Table

Parameter of ComparisonPhenterminePhentramine
Type of drugPrescription drugPharmaceutical grade drug
What is it used forDealing with obesityDealing with obesity
Active IngredientsPhentermine Hydrochloride (HCL)Phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous) 
Inhibiting actionAppetite suppressingAppetite supressing
Available without prescriptionNoYes
AddictiveNoMaybe (not proven)

What is Phentermine?

Phentermine is a short-term weight loss drug, and it is approved by the Food and Drug Administration (FDA) of the United States of America.

It is used to treat excessively obese patients and transition to healthy lifestyle choices such as proper exercise and a nutritious diet.  It can also be called an appetite-suppressing drug.

It is supposed to reduce an individual’s appetite, and it does so by affecting the central nervous system. The active ingredient in phentermine is Phentermine Hydrochloride (HCL)

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It works by stimulating the hypothalamus gland and the affected neurotransmitters. Neurotransmitters are chemicals in the brain through which the brain cells communicate with other cells.

The hypothalamus gland of the brain controls a person’s body temperature, sleep cycles, and appetite; thus, when phentermine is taken, it stimulates the gland and reduces one’s appetite.

Studies have shown that phentermine has been effective in placebo-controlled trials.  The bottom line is that Phentermine is a drug and should be the last option for an obese person. 

If the situation is very bad and they can’t go on without immediate intervention, their doctor might prescribe phentermine.  Phentermine cannot be bought at medical stores without a prescription, and one should not try to take it without a prescription.

Side effects of phentermine include insomnia, depression, anxiety, swelling in the legs, chest pain, increased blood pressure, headaches, and others. 


What is Phentramine?

Phentramine is a pharmaceutical drug graded at the pharmaceutical level. It does not need to be prescribed and supposedly has natural ingredients. Phentramine works by suppressing one’s appetite, increasing energy levels, and boosting the calorie-burning procedure.

It also helps keep one’s blood sugar levels in check. Phentramine can be taken by those wanting to reduce weight and live a healthier life. People using phentramine may be suffering from obesity or may be overweight.

Obesity and overweight are related to cardiovascular diseases, breathing problems, and diabetes. Phentramine acts as a drug that helps with weight loss. Pharmaceutical companies sell it as a dietary supplement. You can buy bottles of 30-60 pills.

The active ingredients in Phentramine are Phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous).

It works on similar lines to Phentermine, but it has different ingredients. These ingredients are capable of increasing metabolism and favouring thermogenesis. Thermogenesis is the body’s heat-producing process, a way to release energy and thus reduce weight.

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Even though Phentramine is not a prescription pill, you should check with your doctor before taking it. If you have any previous conditions, it is best to go to your doctor so that he/she can clear any contradictions.

Phentramine might also have possible effects such as insomnia, anxiety, vertigo, shaking, headaches, nausea and vomiting, frequent urination, tinnitus, etc. No study has proven these side effects, though they are theoretical. 


Main Differences Between Phentermine and Phentramine

  1. Phentermine is an FDA-approved drug. On the other hand, Phentramine is a pharmaceutical drug.
  2. Phentermine is a prescription drug; you cannot buy it without a doctor’s permission. On the other hand, Phentramine is a pharmaceutical-grade drug; you can buy it without a doctor’s prescription.
  3. Phentermine has only one ingredient, Phentermine Hydrochloride (HCL). On the other hand, Phentramine has an array of active ingredients, namely phenylethylamine HCL, R-Beta-Methylphenylethylamine HCL, Methylphenylethylamine Tartrate, Methylsynephrine HCL, N-Methyl-phenylethylamine HCL, Synephrine HCL, Theobromine Anhydrous, Yohimbine HCL, Caffeine (Anhydrous)
  4. Phentermine is proven effective in having a positive effect on patients. On the other hand, no studies have proven the effectiveness of Phentramine, although it is claimed to have similar effects as Phentermine.
  5. Phentermine works by stimulating the brain’s hypothalamus gland, which is responsible for body temperature, sleep, and a person’s appetite. On the other hand, Phentramine works by boosting the metabolism rate and boosting thermogenesis in a person’s body.
  6. Phentermine is not addictive. On the other hand, Phentramine might be addictive.

Last Updated : 11 June, 2023

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22 thoughts on “Phentermine vs Phentramine: Difference and Comparison”

  1. I appreciate the thorough explanation about the differences between Phentermine and Phentramine. It’s important to be well-informed about any medication before using it.

    • Definitely. This article highlights the importance of educating oneself about medications to make informed choices when attempting to lose weight.

  2. It’s concerning to learn about the potential side effects of Phentermine and Phentramine. This article emphasizes the importance of consulting with a doctor before considering weight loss medications.

  3. The comparison table provides a clear overview of the differences between Phentermine and Phentramine. It’s a very useful resource for anyone looking into weight loss medications.

    • Absolutely. Having a detailed comparison like this makes it easier for individuals to understand the distinctions between these medications.

  4. This article is quite informative. It provides a clear comparison between Phentermine and Phentramine, and helps understand their differences and uses in treating obesity.

  5. This article raises awareness about the risks of obesity and provides valuable information about Phentermine and Phentramine. It’s essential for individuals to consider the potential benefits and risks before using these medications.

  6. The article provides a thorough comparison between Phentermine and Phentramine. It stresses the importance of understanding the differences and seeking professional guidance before considering these medications for weight loss.

  7. It’s alarming to learn how many people are affected by obesity worldwide. The details about Phentermine and Phentramine can help individuals make a more informed decision about managing their weight.

  8. The comparison provided between Phentermine and Phentramine is very detailed and useful for anyone considering these medications.

  9. It’s in fact disturbing to know how many people die because of obesity or being overweight. This article made it clear that there are options to help with weight loss, but it is crucial to have medical supervision while using these medications.

  10. The side effects of Phentermine and Phentramine are concerning. While they can help with weight loss, it’s important to consider the potential risks and consult with a healthcare professional.

    • I agree. Side effects are an important consideration and individuals should always seek professional advice before using any weight loss medication.

    • Absolutely. Understanding the potential risks associated with these medications is crucial for anyone considering them for weight loss.


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