Difference Between Acetaminophen and Ibuprofen

One of the most common reasons why people visit medical experts is for pain relief. There are numerous medications available in the market for the same.


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A passenger in a moving bus is thrown forward when the bus suddenly stops. This is explained

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Which of the following compound is mainly used in hand sanitizer?

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Name the process by which the human breathes?

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Which among the following is not a synthetic fiber?

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Chemical formula for water is

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A bond that occurs between nonmetals and nonmetals is called a/an _________.

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What is the fuel in the Sun?

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Non-stick cooking utensils are coated with

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A chemical reaction where energy is released is called:

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Acetaminophen vs Ibuprofen

The difference between acetaminophen and ibuprofen is that acetaminophen can only relieve the user of pain and fever whereas, in the case of ibuprofen, the user can get relief from inflammation as well as pain and fever. This means that ibuprofen 2 has more uses than the former. Some research also suggests that acetaminophen is not as effective as ibuprofen 2 for pain relief.

Acetaminophen vs Ibuprofen

Acetaminophen, often referred to as paracetamol, is an over-the-counter medication used to treat the symptoms of fever and low-moderate pain.

Ibuprofen is an over-the-counter medication that is useful for the treatment of pain, fever as well as inflammation. It is often used by patients suffering from headaches, dental pain, menstrual cramps, muscle aches and even arthritis.

Comparison Table

Parameters of ComparisonAcetaminophenIbuprofen 2profen
UsesAcetaminophen is used to treat mild to moderate pain and fever.Ibuprofen is used to treat pain, fever, as well as inflammation.
Side EffectsSome common side effects of acetaminophen include nausea, itching, rash, headache, loss of appetite and dark urine.Common side effects of ibuprofen 2 include nausea, vomiting, stomach pain, tiredness, tinnitus, and difficulty in breathing.
Functional PrincipleAcetaminophen inhibits the production of prostaglandins in the brain which sensitizes pain.Ibuprofen 2 inhibits COX1 which catalyzes the creation and secretion of prostaglandins.
PrecautionsLong term use or overdose of acetaminophen may cause liver damage.Long term use or overdose of ibuprofen may cause internal bleeding.
SafetyAcetaminophen is relatively safe to use.Ibuprofen should be avoided during pregnancy.

What is Acetaminophen?

Acetaminophen is a medication used to relieve pain and fever. It is also called paracetamol or Tylenol.

On consuming a standard dose of the drug, the body temperature of the user decreases by a slight degree. Acetaminophen also relieves pain that is caused due to acute migraines.

Acetaminophen was first made in the 1800s and was widely used as a medication for fever and pain in the United States as well as Europe. The drug even made it to the list of the World Health Organization’s Essential Medications.


What is Ibuprofen?

Ibuprofen is a nonsteroidal anti-inflammation medication that is used to treat pain, fevers, and inflammation. Some common conditions that it is used to treat are menstrual cramps, migraines, as well as rheumatoid arthritis.

Some common side effects of ibuprofen 2 include nausea, vomiting, heartburn, rashes, stomach upset, tinnitus, tiredness and even difficulty in breathing.

Ibuprofen was discovered in the year of 1961 by Stewart Adams and John Nicholson. Both of them worked at Boots UK Limited. They initially suggested for the drug to be sold under the name ‘Brufen’.


Main Differences Between Acetaminophen and Ibuprofen

  1. Long term use or overdose of acetaminophen may cause liver damage while that of ibuprofen may cause gastrointestinal bleeding.
  2. Acetaminophen is safe to consume during pregnancy while ibuprofen is not.
Difference Between Acetaminophen and Ibuprofen


  1. https://jamanetwork.com/journals/jamapediatrics/article-abstract/485730
  2. https://academic.oup.com/jid/article-abstract/162/6/1277/918184
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