Difference Between Acromegaly and Gigantism

 Two diseases with the same mechanism and very similar manifestations are gigantism and acromegaly. While the disease process is the same, all of them have an entirely different result only because of the starting age.


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Acromegaly vs Gigantism

The difference between acromegaly and gigantism is that acromegaly is the growth hormone over secretion that starts with age. The death rate of acromegaly is two to three times that of the population as a whole. Until epiphysis fusion at puberty, gigantism can start at any era. Gigantism is an exaggeration of the growth hormone that occurs in infancy.

Acromegaly vs Gigantism

Acromegaly is the outcome as puberty begins the disease mechanism. More common than gigantism is acromegaly. It begins in around the 3rd decade of acromegaly.

Gigantism mortality rates in infancy are not understood because of the limited cases. The outcome is gigantism, as the mechanism of the disease begins in infancy.

Comparison Table

Parameters of ComparisonAcromegalyGigantism
DefineAcromegaly is a disease in which the growth hormone secreted starts between the ages of 20 and 40 at some point.Gigantism is a condition in which the growth hormone secreted during infancy is excessive.
Life cycleDuring early to middle age, acromegaly progresses.During childhood, gigantism always occurs before the bones’ growth plate fusion.
FeaturesThe tongue also changes size and form in acromegaly, the jaw often emerges, and the lips thicken.The jaw is pronounced with gigantism, and the front rises.
HeightAn individual with acromegaly has no higher height as the disorder begins in adulthood.An individual with gigantism has increased, and it is already increasing in children.
 PubertyAfter puberty and during maturity, acromegaly progresses so that it does not begin.Until puberty, gigantism occurs and will also prolong the onset of puberty

What is Acromegaly?

Acromegaly is the oversecretion of the growth hormone of the hypophysis from 20 to 40 years of age. The first signs are facial changes and a rough appearance.

The measurement and observation of elevated levels of growth hormones in the blood plasma as well as CT or MRI scans will diagnose acromegaly.

It may arise from a non-carcinogenic hyperphysical tumor or a non-hyperphysical tumor in another area of the brain, lungs, or pancreas.

The respiratory system and lipid and glucose metabolism can also be more and more problematic. Chirurgical surgery with the removal of the tumor is possible, and radiation treatment can also be helpful.

What is Gigantism?

Gigantism is a condition in which an accumulation of growth hormone in a person’s youth is released from the pituitary gland. It happens before the assembly and fusion of epiphyseal (growth) plates of bones.

Symptoms include blurred vision, delayed start of pubescent transitions, double vision, pronounced front and chin, elevated pull, and big hands and feet may be present.

The presence of a pituitary adenoma can be seen by an MRI scan or CT scan. This tumor is also activated by the benign, non-cancerous growth hormone of the pituitary gland.

Treatment can cause metabolic complications, such as glucose and lipid metabolism. If not treated, cardiovascular problems can increase later in life.

Main Differences Between Acromegaly and Gigantism 

  1.  Gigantism is quite uncommon, whereas acromegaly is common.
  2. An individual with acromegaly has no higher height as the disorder begins in adulthood, whereas an individual with gigantism has increased, and it is already increasing in children.


  1. https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23121
  2. https://academic.oup.com/jcem/article-abstract/8/12/1013/2720311
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