Difference Between Adjuvanted and Unadjuvanted h1n1 Vaccines

The science and medical field cover vast areas of medicines and vaccines. Under the subject of vaccines, there exist two kinds of vaccines which are Adjuvanted vaccines and Unadjuvanted vaccines. Adjuvanted vaccines contain chemicals that help boost one’s immune system while on the other hand, Unadjuvanted vaccines contain no such boosting chemical. 

Adjuvanted vs Unadjuvanted h1n1 Vaccines

The main difference between adjuvanted and unadjuvanted h1n1 vaccines is that the former contains a chemical substance that helps enhance the immune system of one’s body and thus provides better protection against the disease affecting one’s health while on the other hand, the latter has no such boosting chemical substance embedded in itself.


Adjuvanted h1n1 vaccines inject a chemical substance called “adjuvant” into the body of the diseased. Adjuvant gets its name from the Latin word adiuvare which refers to help or aid. An adjuvant is a chemical that enhances the immune power of the diseased body. It makes the vaccine more effective and powerful. 

Unadjuvanted h1n1 vaccines don’t contain an adjuvant or any such immunity-boosting chemical substance (unlike an adjuvanted vaccine). Unadjuvanted vaccines are a much safer option than adjuvanted vaccines. These vaccines are built up in a way to cure diseased people without the use of any immunity-enhancing agent which is called an adjuvant. 

Comparison Table Between Adjuvanted and Unadjuvanted h1n1 Vaccines

Parameters of Comparison Adjuvanted h1n1 VaccinesUnadjuvanted h1n1 Vaccines
SignificanceThese vaccines contain a chemical agent named adjuvant which boosts one’s immunity.These types of vaccines don’t contain an immunity-boosting agent.
Tumor OccurrenceTumor occurrences are majorly present.Tumor occurrences are not present in this case.
SafetyAdjuvanted vaccines may cause a few local reactions on the body of the patient.Unadjuvanted vaccines are comparatively a safer alternative than adjuvanted vaccines as they don’t cause any local reactions.
AdvantagePromotes cell-mediated immune responses and strengthens immunity.The vaccines cause little or absolutely no risk of sarcoma.
ExamplesCervarix, fluad, anthrax, DTAP, DT, havrix, etc.Vaccines for chickenpox, IPOL, mumps, measles, rubella, etc.

What are Adjuvanted h1n1 Vaccines?

Adjuvanted h1n1 vaccines inject a chemical substance called adjuvant into the body of the diseased. “Adjuvant” means help or aid in Latin. It is an immunity-enhancing chemical substance that reduces the amount of virus needed to produce such vaccinations. 

These vaccines may cause certain local reactions on the body like redness, swelling, pain in the area of injection, etc. They may also lead to some systematic reactions like fever, chills, tiredness, etc. This makes adjuvanted vaccines a little risky to use.

Adjuvants made of aluminum could be a threat to the body as their residues could lead to the formation of tumors. These are aggressive tumors (sarcoma) that occur at the site of vaccination. If not detected early, these tumors could lead to a serious and cradle disease – cancer.

Below is a list of a few adjuvants used in adjuvanted vaccines:

  • Aluminum- contains aluminum hydroxide, aluminum phosphate, potassium aluminum sulfate, and aluminum hydroxyphosphate sulfate.
  • AS04- aluminum salt and monophosphoryl lipid A.
  • MF59- oil in water emulsion composed of squalene.

Adjuvanted h1n1 vaccines overall help in aiding the health problem of swine flu using an adjuvant that enhances or boosts the immune system of the diseased. It reduces the virus content in the injection.

What are Unadjuvanted h1n1 Vaccines?

Unadjuvanted h1n1 vaccines refer to those kinds of vaccines that don’t contain an immune-enhancing adjuvant. They lack an immunity-boosting chemical substance. These vaccines are made in such a way that they serve their purpose without the need of an adjuvant.

These types of unadjuvanted vaccines don’t usually lead to any serious health condition. They don’t cause any local reaction ( like redness, swelling, and pain in the area of injection ) or systematic reaction ( like tiredness, fever, and chills ). This is the reason why unadjuvanted vaccines are safer than adjuvanted vaccines.

Vaccines that don’t inject an adjuvant into the body of the diseased area are at a little risk of causing a tumor. They often aren’t a cause of any such cancer-causing tumor which is called sarcoma. This is another reason why unadjuvanted vaccines are a safer alternative than adjuvanted vaccines.

Given below are a few examples of unadjuvanted h1n1 vaccines:

  • Zostavax – live zoster 
  • MMR – measles, mumps, and rubella 
  • IPOL – single antigen polio 
  • Menactra – meningococcal 
  • Menveo

Unadjuvanted h1n1 vaccines overall help in aiding the health problem of swine flu or h1n1 without using an immune strengthening adjuvant. These are the safest options out there in the medical field.

Main Differences Between Adjuvanted and Unadjuvanted h1n1 Vaccines

  1. Adjuvanted h1n1 vaccines contain a chemical called adjuvant while on the other hand unadjuvanted h1n1 vaccines don’t contain an adjuvant.
  2. Adjuvanted h1n1 vaccines are a little riskier than unadjuvanted h1n1 vaccines.
  3. Tumor occurrences are quite likely to take place in the case of an adjuvanted h1n1 vaccine which is very unlikely to occur in the case of an unadjuvanted h1n1 vaccine.
  4. Local reactions like redness, swelling, fever, and body ache may occur due to an adjuvant while on the other, hand no such reaction occurs in the case of an unadjuvanted h1n1 vaccine.
  5. Examples of adjuvanted h1n1 vaccines are DT, DTAP, fluad, and Cervarix while on the other hand examples of unadjuvanted h1n1 vaccines are MMR, zostavax, menveo, Menactra, etc.


Swine flu or h1n1 disease can be cured with the help of two types of vaccines. One of them is an adjuvanted h1n1 vaccine and the other is an unadjuvanted h1n1 vaccine. The former has an immunity-boosting chemical agent called adjuvant which lacks in the latter.

An adjuvanted h1n1 vaccine may lead to certain local health reactions like tiredness, skin irritation, fever, and nausea. These reactions won’t occur if one is injected with an unadjuvanted h1n1 vaccine. A tumor is also one of the serious illnesses caused due to an adjuvant injected into a patient’s body.

Both types of vaccines have their own pros and cons. They work effectively under their respective mechanisms.


  1. https://www.nejm.org/doi/full/10.1056/nejmoa0907650
  2. http://www.differencebetween.net/science/health/difference-between-adjuvanted-and-unadjuvanted-h1n1-vaccines/
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