Difference Between Diclofenac Sodium and Diclofenac Potassium

People face pain sometimes in their joints or a headache, and the pain becomes unbearable sometimes due to which person needs to take some kind of medication to treat the pain. In this kind of pain, the doctors prescribe them to consume the medicines which contain Diclofenac.


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It can be Diclofenac Sodium or Diclofenac Potassium.

Key Takeaways

  1. Both are nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain, inflammation, and stiffness, but they differ in chemical forms: sodium and potassium salts.
  2. Diclofenac potassium is absorbed more rapidly, providing faster pain relief, while diclofenac sodium offers a slower onset of action.
  3. Diclofenac potassium is recommended for acute conditions, such as muscle sprains, while diclofenac sodium is more suitable for chronic conditions, like osteoarthritis.

Diclofenac Sodium vs Diclofenac Potassium

The difference between Diclofenac Sodium vs Diclofenac Potassium is Diclofenac Sodium is less soluble in water as compared to Diclofenac Potassium. Diclofenac Potassium treats the pain quickly or can be said faster than Diclofenac Sodium. Diclofenac Potassium can treat severe pains quickly, while Diclofenac Sodium is used during mild pain in the body.

Diclofenac Sodium vs Diclofenac Potassium

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Diclofenac Sodium is a nonsteroidal anti-inflammatory drug. It is applied by using a dosing card which is available with the medicine. It is applied directly to the skin.

The medication has to be run on the surface where pain exists. The medication should be applied four times a day. This should not be applied to cuts as it can show side effects.

Diclofenac Potassium is used to treat mild pain. It is used when the pain is mild or moderate. It treats pain in the tooth, cramps, or muscles.

It is also termed a non-steroidal anti-inflammatory drug. It can treat arthritis, but this should be prescribed by the doctor. Its rate of speed is high.

Comparison Table

Parameters of ComparisonDiclofenac SodiumDiclofenac Potassium
UsageMild PainSevere Pain
Chronic MuscleYesNo

What is Diclofenac Sodium?

Diclofenac Sodium is a non-steroidal anti-inflammatory drug. It can also be referred to as the sodium salt of Diclofenac. It is a antipyretic and analgesic.

It has anti-inflammatory activity. It is stored in labs with high security, and there are signs like a health hazard, environmental hazard, irritant, and acute toxicity.

It is considered a competitive inhibitor of cyclooxygenase. The arachidonic acid cannot be converted to any other precursors. It seizes the growth of the prostaglandins, which grow during the pain or fever.

It releases the pain and makes you feel better. It cannot be consumed in a larger portion as the pain is a lot.

It has to be consumed in the proper amount. It has to be consumed as per the doctor’s prescription. Many other brands are there who sell these types of medicines under their name.

Those brands are Arthrotec, Solaraze, and Voltaren. The symptoms of Diclofenac Sodium are drowsiness, headache, diarrhea, nausea, and many more.

It is also known as Voltaren overdose when the person consumes the medicine in a higher dose. The medicine has to be swallowed; otherwise, the medicine can increase the side effects.

The medicines are prescribed and always be consumed as per the doctor’s instruction; otherwise, it can create problems in the body.

diclofenac sodium

What is Diclofenac Potassium?

Diclofenac Potassium is one of the nonsteroidal anti-inflammatory drugs. It is used to treat Mild pain, or it can treat moderate pain. It treats the pain in the back, stomach, or teeth.

These conditions can slow down and make you lazy about yourself. These conditions need instant treatment because they can stop you from doing your daily activities.

The dosage of the medicine should only be consumed after you prescribe the doctor. The overdose of the dosage can show adverse effects or side effects that cannot be controlled later on.

The dosage should be taken as much as prescribed by your doctor. The speed of reaction is faster, so it will quickly treat the pain.

The medicine can also decrease swelling or fever in the body. The medication is to be mixed with only water.

There should not be any liquid other than water. Sometimes it can make your stomach upset, so it should be consumed with food, antacid, or milk. Different brands sell this type of medicine.

The medications should always be started in the first phase of pain; otherwise, if the pain increases, then it would be difficult to treat the pain. Sometimes the pain can be a symptom of a big problem. The medication should be started in the first phase of the pain.

diclofenac potassium

Main Differences Between Diclofenac Sodium and Diclofenac Potassium

  1. Diclofenac Sodium is less soluble than Diclofenac Potassium.
  2. The reactive process is slow in Diclofenac Sodium than in Diclofenac Potassium.
  3. Diclofenac Sodium is used in mild pain, but Diclofenac Potassium is used in severe pain.
  4. Diclofenac Sodium can also treat chronic muscle pain, but Diclofenac cannot treat chronic pain.
  5. Diclofenac Sodium can cause heartburn, but Diclofenac Potassium cannot cause heartburn.
  6. Diclofenac Potassium can cause constipation, and Diclofenac Sodium cannot cause constipation. 
  1. https://www.sciencedirect.com/science/article/pii/S0099542808603664
  2. https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2125.2005.02226.x
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