Hashimotos vs Lupus: Difference and Comparison

Lupus can happen to people of all age groups, and it is not a specific age problem. Lupus can be debilitating, and it’s important to understand the symptoms so you can get help if needed.

Hashimoto’s Disease is also an autoimmune disease that primarily targets the thyroid gland. Both diseases are on the rise, and they have several similarities.

Key Takeaways

  1. Hashimoto’s is an autoimmune thyroid disorder, while Lupus is an autoimmune disease affecting multiple body systems.
  2. Hashimoto primarily targets the thyroid gland, causing hypothyroidism, whereas Lupus can cause inflammation in various organs.
  3. Treatment for Hashimoto focuses on hormone replacement therapy, while Lupus management involves immunosuppressive medications and corticosteroids.

Hashimotos vs Lupus

The difference between Hashimotos and Lupus is that Hashimotos does not directly attack the heart and kidneys, but Lupus attacks the heart and kidneys. Goiter is present in Hashimotos, but Goiter is not present in Lupus. Patients with Hashimoto’s do not have any joint pain, but Patients with Lupus have joint pain.

Hashimotos vs Lupus

Hashimoto’s Disease is an autoimmune thyroid disorder that causes the immune system to attack healthy tissue in the thyroid gland. It can also lead to other problems throughout the body.


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Hashimoto’s Disease is an autoimmune disease. This means that your immune system decides to attack you and your thyroid gland.

Lupus is a chronic, autoimmune disease that can affect the whole body, causing inflammation and pain. It can be extremely painful, and it can lead to many different health problems.

Some other rheumatic diseases are similar to Lupus which makes diagnosis difficult. It can be difficult to diagnose due to its wide variety of symptoms.

Comparison Table

Parameters of ComparisonHashimotosLupus
GoiterPresentNot present
KidneyNot directly attackedDirectly attacked
HeartNot directly attackedDirectly attacked
RashNoButterfly-shaped rash
TreatmentThyroid hormone replacementCorticosteroid medications
Joint PainNoYes

What is Hashimotos?

Hashimoto’s thyroiditis is an autoimmune disease that affects women more often than men and can lead to several complications. This is a condition that most commonly affects women, but it can also affect men.

More than ten percent of people with this disease are men, which is just as common as breast cancer in the United States.

Autoimmunity starts for many reasons, including genetics, environment, and toxins. Hashimoto’s thyroiditis is a common cause of hypothyroidism in people over 50.

The condition is named after the Japanese physician that first described it, Dr Hakaru Hashimoto, who published a paper titled “Anatomical and Clinical Observations on the Thyroid Gland” in 1914.

The thyroid gland produces hormones that regulate the body’s metabolism, which controls how fast your body uses energy, makes proteins, and controls heart rate.

Hashimoto’s is an autoimmune disorder in which your immune system attacks your thyroid gland because it mistakenly believes you have a foreign body in your body, such as bacteria or a virus.

When this happens, it causes inflammation in the thyroid gland and lowers its ability to produce certain hormones.

This increases the risk of other diseases. Hashimoto’s Disease is more common than you think. It causes the thyroid to swell up, which can lead to extreme fatigue, weight gain, depression, and hair loss.

What is Lupus?

Lupus is a chronic autoimmune disease that affects more than 1.5 million people in the United States. This condition often mimics other illnesses and may even disappear for periods only to reappear months or years later.

The most common symptom is a rash across the bridge of the nose and cheeks, which appears in the morning after waking up.

Other symptoms include pain in your joints, fever, fatigue, hair loss, mouth ulcers, and skin lesions. Lupus is one of the most common yet least understood autoimmune diseases. This results in an inadequate level of funding for research and treatment.

The Lupus Foundation of America works to raise awareness and fund lupus research to find better treatments and a cure for this complex disease, lupus, a disease that causes the body’s immune system to attack healthy tissue.

It causes extreme pain throughout the body and has symptoms of arthritis, fever, fatigue, rashes on the face or hands (but not on palms), nose and mouth lining inflammation, hair loss (alopecia), muscle aches, and joint pain.

It can severely damage internal organs, including the kidneys, lungs, brain, and heart. The symptoms vary from person to person but also affect internal organs. In some cases, people diagnosed with Lupus have been found to have blood clots.

Main Differences Between Hashimotos and Lupus

  1. Goiter is present in the neck in Hashimoto’s Disease but not present in Lupus.
  2. Kidneys are not directly attacked in Hashimotos but are directly attacked in Lupus.
  3. The heart is not directly attacked in Hashimotos but is directly attacked by Lupus.
  4. Patients who have Hashimotos do not have a butterfly-shaped rash, but Patients who have a rash have a butterfly-shaped rash.
  5. Hashimotos is treated by using thyroid hormone replacement therapy, but Lupus cannot be treated with the same.
  6. Joint pain does not happen in Hashimotos but happens in Lupus.
Difference Between Hashimotos and Lupus
  1. https://www.sciencedirect.com/science/article/pii/S1521690X19301186
  2. https://jasn.asnjournals.org/content/10/2/413.short
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