Myasthenia Gravis vs Multiple Sclerosis: Difference and Comparison

When it comes to neuromuscular disorders affects nerves that manage voluntary muscles. It also affects the nerve, which communicates sensory information reversers to the brain.

Myasthenia Gravis and Multiple Sclerosis are two neuromuscular disorders that have an autoimmune cause.  

In these disorders, a person’s immune system can cause these certain tissues to be attacked by the body. In general, it is a situation that shows symptoms involving functions.

Apart from similarities, there are several differences between Myasthenia Gravis and Multiple Sclerosis covered in this article. 

Key Takeaways

  1. Myasthenia gravis results from a breakdown in communication between nerves and muscles, while multiple sclerosis involves damage to the protective covering of nerve fibers.
  2. Myasthenia gravis primarily affects muscle strength, causing weakness and fatigue, whereas multiple sclerosis impacts various body systems, leading to many symptoms.
  3. Treatment for myasthenia gravis focuses on improving muscle function, while multiple sclerosis management aims to slow disease progression and alleviate symptoms.

Myasthenia Gravis vs Multiple Sclerosis 

Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junctions, which are the points where nerve cells meet muscle cells. Multiple sclerosis is also a chronic autoimmune disorder that affects the central nervous system, which includes the brain and spinal cord.

Myasthenia Gravis vs Multiple Sclerosis
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Myasthenia gravis is a neuromuscular disease that leads to skeletal muscle weakness. The body uses skeletal muscles for movement.

In this, communication between muscles and nerve muscles becomes impaired. It is a crucial impairment that prevents the occurrence of crucial muscle contractions and results in muscle weakness.

Multiple sclerosis is a chronic condition that involves the central nervous system. The immune system attacks myelin (the protective layer around nerve fibres).

It causes temporary lesions and inflammation. It can lead to lasting lesions caused by scar tissue. 

Comparison Table

Parameters of Comparison Myasthenia Gravis Multiple Sclerosis 
InterpretationIt is rapid fatigue of voluntary control muscle.In this disease, protective covering nerves are eaten away by the immune system.  
Age of onset20-30s (Peaks in women)
50-60s (Peaks in men)
20-40 years
CauseThymusUnknown
ManifestationsCharcot’s TriadFacial expressions
Mortality rate3-4%50%

What is Myasthenia Gravis? 

Myasthenia gravis, or simply MG, is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness.

Face, eyes, and swallowing are the most frequently affected muscles. A person affected by myasthenia gravis has developed a thymoma or large thymus.  

Myasthenia gravis results in drooping eyelids, trouble walking, double vision, and trouble talking.

An autoimmune disease emerges from antibodies that destroy our block AChR or nicotinic acetylcholine receptors at the junction between the muscle and nerve.

It can be diagnosed by checking reflexes, muscle weakness, and muscle tone,

Myasthenia gravis prevents nerve impulses from contractions of triggering muscle. Most cases are due to IgG3 and IgG3 antibodies that target AChR in the postsynaptic membrane.

Congenital myasthenia is a similar condition that results from the inheritance of neuromuscular junction defects.  

The initial symptoms of myasthenia gravis are the painless weakness of particular muscles but not fatigue. It can be diagnosed by checking reflexes, muscle tone, and muscle weakness.

The weakness of muscles becomes progressively worse during the time of physical activity. Typically, fatigue and weakness are worse toward the end of the day. 

myasthenia gravis

What is Multiple Sclerosis? 

Multiple sclerosis is the most common demyelinating disease. The nerve cells insulating covers in the spinal cord and brain are damaged in this. There is no cure available for multiple sclerosis.  

The damage to the spinal cord and brain results in the disruption of nervous system parts which transmit signals. Mental, physical, and sometimes psychiatric problems are its symptoms and signs.

Some of the specific symptoms included are muscle weakness, double vision, and trouble with coordination or sensation.  

When the cause is unclear, the underlying mechanism is thought to be either failure of the myelin-producing cells on destruction by the immune system.

The proposed cause for multiple sclerosis includes environmental and genetic factors.  

Treatments for multiple sclerosis attempt to prevent new attacks and improve function after an attempt. People’s ability to function can improve through physical therapy.

Most people pursue alternative treatments. It is difficult to predict long-term outcomes, but good outcomes can be seen in women. 

Main Differences Between Myasthenia Gravis and Multiple Sclerosis 

  1. Treatment options available for myasthenia gravis are thymus gland removal, medication, and plasma exchange. But there is different treatment for specific symptoms of multiple types of sclerosis, such as antibodies and self-injectable medications.  
  2. Myasthenia gravis can be diagnosed by checking reflexes, muscle tone, and muscle weakness. On the flip side, multiple sclerosis can be diagnosed by blood tests, MRI scans, and VEP or visually evoked potential tests.  
  3. When it comes to complications, the most dangerous of myasthenia gravis is the myasthenic crisis in which there is a life-threatening weakness of muscles, while the complication of multiple sclerosis is mobility issues which can increase the risk of bone fractures.  
  4. The signs of myasthenia gravis are double vision, hoarse voice, and facial paralysis. On the other hand, muscle weakness, difficulty balancing, and muscle spasticity are signs of multiple sclerosis.  
  5. In terms of risk factors, obesity, physical activity, and insufficient diet are risk factors for myasthenia gravis. But the risk factors of multiple sclerosis are smoking, certain autoimmune disorders, and infections. 
Difference Between Myasthenia Gravis and Multiple Sclerosis
References
  1. https://www.jci.org/articles/view/29894
  2. https://books.google.com/books?hl=en&lr=&id=TrdFB8JxtaAC&oi=fnd&pg=PR8&dq=multiple+sclerosis&ots=Q5jALaIgci&sig=463uMIhNDkw84SfLJke7DgUBXeY

Last Updated : 11 June, 2023

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