Difference Between Omeprazole and Esomeprazole

The gastroesophageal reflux disease (GRED) is treated by using omeprazole and esomeprazole. These two drugs are also used for some other diseases related to stomach acids.


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Proton pump inhibitors are the family of both omeprazole and esomeprazole. These drugs can hinder the gastric glands and makes the acids at cellular levels.

Omeprazole vs Esomeprazole

The difference between omeprazole and esomeprazole is their dominant level. The omeprazole is less potent than esomeprazole. Both have the same chemical level that results in the same side effects. The omeprazole is the starter medicine, and esomeprazole is introduced after the omeprazole. The omeprazole has two isomers, while esomeprazole has only one isomer. The isomer in Prilosec is processing fastly than the Nexium. It results in increased drug levels in the bloodstream.

Omeprazole vs Esomeprazole

Prilosec and Losec are the brand names for omeprazole. It is a drug to treat gastric-related problems. The omeprazole is a proton pump inhibitor. It shows its effectiveness by taking it through the mouth or by injection.

It is included in the essential medicines list in the World Health Organization(WHO). The omeprazole got its patent in 1978 and came into the medical field in1988.

Omeprazole also causes side effects in the body. Omeprazole is a generic medicine available in the pharmacy. It is the eighth prescribed medicine in the united states.

Nexium is the brand name for esomeprazole. It is used to treat stomach acids. Like omeprazole, it is also taken by mouth or by injection into veins. It got its patent in 1993 and came into usage in 2000.

It is the 103rd most commonly prescribed medicine in the united states. It also causes mild and heavy side effects. Doctors advised being careful while taking these drugs during pregnancy.

Esomeprazole is a proton pump inhibitor(PPI). It works like other PPIs in the body.

Comparison Table

Parameters of ComparisonOmeprazoleEsomeprazole
Brand namesPrilosec is the brand name of omeprazoleNexium is the brand name of esomeprazole.
Treatment timeOmeprazole takes ten days to eight weeksEsomeprazole takes ten days to six months.
Using for duodenal ulcerOmeprazole can be used.Esomeprazole can not be used.
EffectiveOmeprazole is less effectiveEsomeprazole is more effective
Standard dosage20mg capsule daily40mg capsule daily.
Generic nameOmeprazole magnesiumEsomeprazole magnesium

What is Omeprazole?

Omeprazole is a drug used for the treatments of gastroesophageal reflux disease(GRED), peptic ulcer, and other gastric problems. Helicobacter pylori infection can be treated by the triple dosage of omeprazole.

The 20mg capsule is the standard dosage of omeprazole and causes side effects. Omeprazole is not suggested for pregnant women. It increases the plasma binding rate to 95% in the blood.

Omeprazole is a racemate with two equal mixtures. The reports indicate a transfer of a small amount of drug through breastfeeding if the mother taken omeprazole.

It irreversibly blocks the parietal cells with the enzyme that create the acid for gastric. Without this enzyme, digestion can not happen. It increases the methotrexate in plasma.

Since it comes under a proton pump inhibitor, it works on selective cells is irreversible. It is used for both children and adults.

Omeprazole is the combination of sulfinyl sulfer. The omeprazole is observed in the small intestine. It gets stimulated by the food after digestion.

Omeprazole can be detected by examining the plasma or serum in hospitals. The omeprazole is the first proton pump inhibitor made in 1979.

Since the standard dosage is 20mg, it is available in 10mg, 40mg, and 80mg. Losec, Prilosec, Zegerid, Miracid, and Omez are the famous brands producing the omeprazole drug.


What is Esomeprazole?

Esomeprazole is a drug for stomach-related diseases. It indicates the high risk of NSAID-associated generic ulcers. It is used in the treatment of duodenal ulcers, Zollinger-Ellison syndrome, and erosive oesophagitis.

The esomeprazole is more effective than omeprazole. It can easily control the acids in the stomach and make the acid flow into normal. People who take Nexium have better and faster results than Prilosec.

The side effects caused by esomeprazole are headache, diarrhea, nausea, flatulence, decreased appetite, constipation, dry mouth, and abdominal pain.

It also causes risk side effects like unusual bruising or bleeding, unusual tiredness, and yellowing of the eyes or skin. A single dose of esomeprazole will increase the drug level to the peak in plasma.

The repetitive usage of esomeprazole results in kidney problems. It is excreted through kidney and feces of 80 and 20 percent, respectively.

The recommended time for esomeprazole is four to eight weeks. The Nexium will also result in weight gain. The esomeprazole gets metabolized in the liver.

People with a low amount of magnesium in the blood, severe liver disease, a type of kidney inflammation, subacute cutaneous lupus erythematosus can avoid the esomeprazole drugs. It has a bioavailability of 50 to 90%.


Main Differences Between Omeprazole and Esomeprazole

  1. Prilosec is the brand name of omeprazole, and Nexium is the brand name of esomeprazole.
  2. Omeprazole takes ten days to eight weeks for treatment, and esomeprazole takes ten days to six months.
  3. Omeprazole can be used for duodenal ulcers, and esomeprazole can not be used for duodenal ulcers.
  4. Omeprazole is less effective, and esomeprazole is more effective.
  5. The standard dosage of omeprazole is 20mg capsule, and for esomeprazole is 40mg capsule.
Difference Between Omeprazole and Esomeprazole


  1. https://link.springer.com/article/10.2165/00003088-200140060-00003
  2. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2036.2000.00856.x
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