Zyban vs Wellbutrin: Difference and Comparison

Zyban is used as an aid for smoking cessation, while Wellbutrin is a medication that can be prescribed for depression or anxiety. First of all, we need to address how it might seem like a good idea to combine Zyban and Wellbutrin for smoking cessation because of the nicotine in both medications.

There is no evidence that taking these two drugs at the same time can be effective, so please do not try this on your own – it could lead to serious adverse effects.

Key Takeaways

  1. Both Zyban and Wellbutrin contain the same active ingredient, bupropion, which is an antidepressant medication.
  2. Zyban is specifically marketed and prescribed for smoking cessation, while Wellbutrin is prescribed for treating depression and seasonal affective disorder.
  3. Although the medications are similar, their dosages and FDA-approved indications differ.

Zyban vs Wellbutrin

Zyban is a brand name for the medication bupropion, used as an aid to help people quit smoking, and is taken orally in tablet form. Wellbutrin is a brand name for the medication bupropion, which is an antidepressant medication that is also sometimes used to treat seasonal affective disorder.

Zyban vs Wellbutrin

Zyban affects neurotransmitters in the brain differently than Wellbutrin. For example, when you stop smoking, your catecholamine levels rise and can cause anxiety.


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Zyban helps to normalize this response in smokers trying to quit, while Wellbutrin does not have that same effect. Zyban may be more effective at treating other types of depression than Wellbutrin, as Zyban is a different drug with different effects.

Wellbutrin is an antidepressant that is used to treat depression and many other mood problems. Wellbutrin side-effects are common but less severe and include dry mouth or difficulty urinating.

This is not a good idea because there’s no evidence that taking these medications together can be effective. In fact, combining them could lead to serious adverse effects such as irregular heart rate and seizures.

In addition, because of different mechanisms in their work and side effects, there’s no evidence that Wellbutrin can be used to treat smoking cessation.

Comparison Table

Parameters of ComparisonZybanWellbutrin
DefinitionZuban is used for smoking cessation.Wellbutrin is a medication that can be prescribed for depression or anxiety.
MeaningZyban is a drug that can help with both depression and nicotine addiction.Wellbutrin is an antidepressant medication made from bupropion hydrochloride.
Drugs InteractAntidepressants, certain pain relievers, and other drugs may interact with this medication.No clinically significant interactions have been identified at low doses of Zyban for the treatment of smoking cessation in adults; however, a dose-dependent pharmacokinetic interaction has been identified in the treatment of smoking cessation in adolescents.
DrawbacksZyban side effects can include dizziness, nausea, and vomiting. Zyban can cause high blood pressure. The major drawback to taking Zyban is that it may be habit-forming.Wellbutrin has less serious potential side effects: headaches or insomnia.
Benefits Zyban may be more potent, but it is less expensive.Wellbutrin is less likely to cause a seizure.

What is Zyban?

Zyban is a prescription medication that acts as an antidepressant by targeting the brain’s nicotinic acetylcholine receptors. It was designed to help people quit smoking by decreasing nicotine cravings and withdrawal symptoms.

Zyban can also be used for other purposes, such as managing chronic pain or suppressing appetite in some cases of obesity.

Zyban’s effectiveness as a smoking cessation aid can be diminished by the use of alcohol, medicines that contain nitrates, and other substances, such as those found in some cough syrups.

Some common side effects that happen when taking Zyban include dizziness, insomnia, anxiety, nausea, vomiting, or diarrhea. Some more serious reactions can also result from long-term use, such as liver damage and suicidal thoughts.

Zyban is classified as a non-nicotine aid, while Wellbutrin belongs to the selective serotonin reuptake inhibitor (SSRI) group of medicines. Zyban can be prescribed by doctors who are authorized prescribers and is also used for clinical trials on its effectiveness in smoking cessation therapy.

zyban scaled

What is Wellbutrin?

In contrast, Wellbutrin is used more to treat symptoms of depression and anxiety. It can be taken on a long-term basis as the drug has been shown not only to improve mood but also other mental health conditions such as ADHD, bipolar disorder, or post-traumatic stress disorder.

The most common side effects of Wellbutrin are nausea, dry mouth, dizziness, and drowsiness.

Wellbutrin also comes in a liquid formulation which is taken three times daily, just like the tablet form. The drug Wellbutrin is also taken on a long-term basis and has been shown to improve mood as well as other mental health conditions, such as ADHD or bipolar disorder.

One of the most common side effects is nausea; dry mouth, dizziness, and drowsiness are other possible side effects.

Maintenance therapy for people with chronic mental illness who need to take medication every day to help to control their disease. This is a good drug for people who are allergic or sensitive to other types of antidepressants, as well as those with seizure disorders and Parkinson’s Disease.


Main Differences Between Zyban and Wellbutrin

  1. Zyban was originally developed specifically to help people to quit smoking. Wellbutrin is also used as an off-label treatment for cocaine addiction; this type of treatment has not been approved by the FDA, but it could be something that your doctor will discuss with you.
  2. Zyban will help to eliminate withdrawal and is often used as an aid for smoking cessation. Wellbutrin will help with the depressive symptoms that are associated with nicotine addiction by acting on neurotransmitters in different ways than Zyban does.
  3. Zyban will cause more side effects than Wellbutrin does because it affects other parts of the body’s system. Zyban can also have an impact on your heart rate and blood pressure, which may be dangerous for some individuals, as well as having a more severe withdrawal.
  4. Wellbutrin is thought to be safer than Zyban for the heart and blood pressure, but it can have more impact on your weight if you are a smoker trying to quit by taking up Wellbutrin.
  5. Wellbutrin, on the other hand, came out much later and has been shown to be a more effective weight loss agent than Zyban for those trying to stop smoking by taking it as well.
  1. https://search.informit.org/doi/abs/10.3316/INFORMIT.382392503964935
  2. https://pubs.acs.org/doi/abs/10.1021/ed077p1479

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