Difference Between Aciphex and Nexium

We all have experienced bad stomachs in our life and hence it is one of the noticeable health conditions and should not be ignored at any cost.

Gastritis is the term used for this condition and it is caused by infection, too much consumption of liquor, or even pain killers.

If such things are not treated on time it can even cause internal bleeding in the stomach.

Aciphex and Nexium are two highly recommended medications by the doctor for controlling stomach acid which might cause gastroesophageal reflux disease (GERD) and duodenal ulcers.

Aciphex vs Nexium

The main difference between Aciphex and Nexium is that they are the generic names for different drugs. Aciphex is the generic name used for the drug called Rabeprazole. And on the other hand, Esomeprazole is the main drug named for which Nexium has been chosen as the generic name.

Aciphex vs

Aciphex is a medication that is widely used to treat heartburns and ulcers.

Aciphex does not interact with every other drug, but the drugs that can be used along with Aciphex are named Digoxin, Blood Thinners, Diuretics, Methotrexate, etc.

On the other hand, the stomach conditions such as heartburns and stomach ulcers are treated with the help of Nexium.

It can interact with some specific drugs which include Plavix, Invirase, Valium, Petal, etc. Also, Aciphex is a strong medicine that should not be consumed without the doctor’s consultancy.

Comparison Table Aciphex and Nexium

Parameters of ComparisonAciphexNexium
FDAFor the first time, Aciphex was approved by FDA on 19th August 1999.On 23rd November 2015, Nexium was approved by FDA.
Brand/Generic NameAciphex is the branding name for the drug Rabeprazole. Nexium is the generic term used for a drug named Esomeprazole.
Dosage Type Aciphex only comes in the pill version. Nexium is available in three different versions which include pills, injections, and packets.
Side Effects Aciphex can also lead to some severe side effects like hepatitis, swelling, muscle pain, joint pain, etc. A few side effects that can be caused by Nexium are diarrhea, vomiting, headaches, stomach ache, gas, etc.
EffectivenessAciphex shows its effectiveness faster. Nexium works a bit late than Aciphex.

What is Aciphex?

We all have experienced the feeling of a bad stomach and therefore it can lead to various other diseases that require medications.

And, Aciphex is on such medication used to cure heartburns and ulcers inside the stomach.

Doctors widely recommend Aciphex for the conditions such as Gastroesophageal Reflux Disease (GERD), Helicobacter pylori which is a bacterial infection, and duodenal ulcers and Aciphex is quite effective in such problems.

As we all know that, Aciphex is only the brand name for the medication and therefore the main drug is called Rabeprazole.

It was approved by FDA around 19th August 1999 and since then it has been a highly demanded drug. Aciphex is a great medication and it takes less time to show its effects and therefore enables the consumer to get relief within a short time.

It not only gives relief to the patient but sometimes it might cause some side effects. Some major side effects of Aciphex are hepatitis, swelling, joint pain, etc. Hence, the patient should seek medical help.

Aciphex is only available in the form of pills. And therefore, it is available in the two-pill form which includes tablets and capsules.

The strengths for DR- tablets are 20 mg and the strengths for DR-capsule are 5 mg and 10mg. The doctors prescribe it to the patients as per their requirements.

What is Nexium?

Nexium is a widely used drug for heartburns and stomach ulcers. Such conditions are very serious conditions and Nexium is one of the most preferred drugs for it.

Nexium has come into force a few years ago. It has been recognized by the FDA and hence certified on 23rd November 2015.

The only con of Nexium is that it takes time to show its effect upon the patients’ bodies. Generally, Nexium is the highly recommended use for treating Esophagus as well as stomach problems like Acid Reflux, ulcers, etc.

The drug that has been named after Nexium is Esomeprazole which is best for the stomach. Nexium also has some minor, side effects and the side effects are headache, stomach pain, vomiting, etc.

If such things happen then you should consult a doctor and change the drug.

Nexium comes in several forms like pills, injections, and packets.

One can choose any of these accordingly to their convenience as the people who are afraid of infections can take pills and the ones who are afraid of pills can take injections.

It’s all about personal choice. There are two strengths for Nexium, the Gastro-Resistant tablets and they are 20mg and 40mg.

Main Differences Between Aciphex and Nexium

  1. FDA initially, approved Aciphex on 19th August 1999 while on the other hand, Nexium was approved a bit later on 23 November 2015.
  2. A drug named Rabeprazole is sold by using the name Aciphex while on the other hand, the brand name chosen for Esomeprazole is Nexium.
  3. The Aciphex is available in the form of pills while on other hand, Nexium can be purchased in different versions such as pills, injections, and packets.
  4. Hepatitis, swelling, muscle pain, joint pain, etc are some side effects of Aciphex while on the other hand, Nexium can affect our body in a negative way where its side effects include diarrhea, vomiting, headaches, stomach ache, gas, etc.
  5. It takes less time for Aciphex to show its effects upon the patient’s body while on the other hand, Nexium comparatively takes a longer time to work.


As we have come to know, Aciphex and Nexium are two drugs used for curring stomach conditions.

People often ignore stomach problems but later it might cause some serious issues such as stomach ulcers, therefore the doctors prescribe various medications and Aciphex and Nexium are some of them.

The main drugs used for each of them are different from each other.

The effectiveness also differs from each other. Their strengths also differ from each other, the doctors prescribe the patients according to their type.


  1. https://www.sciencedirect.com/science/article/pii/S1359644609001159
  2. https://www.tandfonline.com/doi/abs/10.3109/J058v17n03_04
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