Aciphex vs Nexium: Difference and Comparison

We all have experienced bad stomachs in our life,; hence, it is one of the noticeable health conditions and should not be ignored at any cost.

Gastritis is the term used for this condition, and it is caused by infection, too much consumption of liquor, or even painkillers.

If such things are not treated on time, it can even cause internal bleeding in the stomach.

Aciphex and Nexium are two highly recommended medications by the doctor for controlling stomach acid, which might cause gastroesophageal reflux disease (GERD) and duodenal ulcers.

Key Takeaways

  1. Aciphex (rabeprazole) and Nexium (esomeprazole) are proton pump inhibitors for treating acid reflux and related conditions.
  2. Aciphex works more rapidly than Nexium in suppressing acid production.
  3. Both medications have similar side effects and interactions, but the individual response may vary.

Aciphex vs Nexium

Aciphex, also known as Rabeprazole, treats gastroesophageal reflux disease (GERD), a condition in which stomach acid flows back into the esophagus and causes heartburn and other symptoms. Nexium, also known as esomeprazole, is used to treat GERD and different needs related to excess stomach acid.

Aciphex vs

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Aciphex is a medication that is widely used to treat heartburn and ulcers.

Aciphex does not interact with every other drug, but the drugs that can be used along with Aciphex are named Digoxin, Blood Thinners, Diuretics, Methotrexate, etc.

On the other hand, the stomach conditions such as heartburn and stomach ulcers are treated with the help of Nexium.

It can interact with specific drugs, including Plavix, Invirase, Valium, Petal, etc. Also, Aciphex is a strong medicine that should not be consumed without the doctor’s consultancy.

Comparison Table

Parameters of ComparisonAciphexNexium
FDANexium is available in three different versions, including pills, injections, and packets. For the first time, Aciphex was approved by FDA on19 Augustt 1999.
Brand/Generic NameAciphex is the branding name for the drug Rabeprazole. Nexium is the generic term used for a drug named Esomeprazole.
Dosage Type Aciphex only comes in the pill version. Nexium works a bit later than Aciphex.
Side Effects Aciphex can also lead to some severe side effects like hepatitis, swelling, muscle pain, joint pain, etc. A few side effects that can be caused by Nexium are diarrhea, vomiting, headaches, stomach ache, gas, etc.
EffectivenessAciphex shows its effectiveness faster. Nexium works a bit late than Aciphex.

What is Aciphex?

We all have experienced the feeling of a bad stomach and therefore it can lead to various other diseases that require medications.

And Aciphex is the such medication used to cure heartburns and ulcers inside the stomach.

Doctors widely recommend Aciphex for the conditions such as Gastroesophageal Reflux Disease (GERD), Helicobacter pylori which is a bacterial infection, and duodenal ulcers Aci.phex is quite effective in such problems.

As we all know, Aciphex is only the brand name for the medication; therefore,, the primary drug is Rabeprazole.

FDA approved it around19 Augustt 1999, and since then, it has been a highly demanded drug. Aciphex is an excellent medication, that takes less time to show its effects and therefore enables the consumer to get relief within a short time.

It not only gives relief to the patient,, but sometimes it might cause some side effects. Some significant side effects of Aciphex are hepatitis, swelling, joint pain, etc. Hence, the patient should seek medical help.

Aciphex is only available in the form of pills. And therefore, it is available in the two-pill form,, including tablets and capsules.

The strengths for DR- tablets are 20 mg, and DR-capsule are 5 mg and 10mg. The doctors prescribe it to the patients as per their requirements.

What is Nexium?

Nexium is a widely used drug for heartburn and stomach ulcers. Such conditions are severe, and Nexium is one of its most preferred drugs.

Nexium has come into force a few years ago. It wwas recognized by the FDA and certified on23 Novemberr 2015.

The only con of Nexium is that it takes time to show its effect on the patients’ bodies. Generally, Nexium is highly recommended use for treating Esophagus and stomach problems like Acid Reflux, ulcers, etc.

The drug named after Nexium is Esomeprazole which is best for the stomach. Nexium also has some minor side effects, including headache, stomach pain, vomiting, etc.

If such things happen,, you should consult a doctor and change the drug.

Nexium comes in several forms,, like pills, injections, and packets.

One can choose any of these accordingly to their convenience, as the people who are afraid of infections can take pills, and those who are so scared of medications can take injections.

It’s all about personal choice. There are two strengths for Nexium, the Gastro-Resistant tablets, and they are 20mg and 40mg.

Main Differences Between Aciphex and Nexium

  1. The FDA initially approved Aciphex on 19 August 1999; on the other hand, Nexium was approved a bit later on 23 November 2015.
  2. A drug named Rabeprazole is sold using the name Aciphex while on the other hand, while another brand name chosen for Esomeprazole is Nexium.
  3. The Aciphex is available in the form of pills, while on the other hand, Nexium can be purchased in different versions such as pills, injections, and packets.
  4. Hepatitis, swelling, muscle pain, joint pain, etc., are some side effects of Aciphex on the other hand, Nexium can affect our body in a negative way, and its side effects include diarrhoea, vomiting, headaches, stomach ache, gas, etc.
  5. It takes less time for Aciphex to show its effects upon the patient’s body, while on the other hand, Nexium comparatively takes a longer time to work.

Last Updated : 01 July, 2023

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