Amphetamine vs Methamphetamine: Difference and Comparison

People always get confused about drugs and their effects. Since they sound similar, they are different drugs used for various purposes.

The chemical makeup of the drug also looks similar. Both of them have distinct properties and characteristics.

Both of them cause many side effects in individuals. Amphetamine and methamphetamine are stimulant drugs for the central nervous system.

Key Takeaways

  1. Amphetamine, a stimulant, treats ADHD and narcolepsy, while methamphetamine is an illegal, highly addictive drug.
  2. Methamphetamine has a stronger impact on the central nervous system than amphetamine due to its faster absorption and more potent effects.
  3. Methamphetamine poses a higher risk of addiction, overdose, and health consequences than amphetamine.

Amphetamine vs Methamphetamine

The difference between Amphetamine and Methamphetamine is their addictive nature. Amphetamine is more addictive when compared to methamphetamine. Amphetamine is used widely for medical purposes, but methamphetamine is not used for medical purposes. Amphetamine is less potent, whereas methamphetamine is more potent since 2015, methamphetamine has a sub-class of amphetamine and then divided into a separate class.

Amphetamine vs Methamphetamine

Amphetamine is a drug used to stimulate the central nervous system. It is used to treat Attention Deficit Hyperactivity Disorder(ADHD).

Disorders like narcolepsy and obesity are also treated with amphetamine. In 1887, the drug amphetamine was discovered. At first, it exists with two enantiomers.

They are Levoamphetamine and dextroamphetamine. In pure amine forms, the chemical is equally divided.

The term amphetamine is used to denote the enantiomers and also for single usage. In ancient days, the amphetamine drug was used to treat congestion and depression.

Methamphetamine is also a stimulant drug used to treat many disorders. It is used to treat the central nervous system.

Methamphetamine is a recreational drug that is used in second-line treatment. In 1893, the drug methamphetamine was discovered. It exists in two enantiomers.

They are levo-methamphetamine and dextro-methamphetamine. Like amphetamine, methamphetamine is also equal in the base mixture in pure amine forms.

Methamphetamine is not a prescribed medicine in recent days. Due to its heavy neurotoxicity, it is not prescribed.

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Comparison Table

Parameters of comparisonAmphetamineMethamphetamine
EffectsAmphetamine is less effectiveMethamphetamine is more effective
Long-lastingAmphetamine will not last for a long timeMethamphetamine is long-lasting
VigorousAmphetamine is less vigorousMethamphetamine is more vigorous
Medical purposeAmphetamine is used for medical purposesMethamphetamine is not used for medical purposes
Side effectsAmphetamine cause changes in blood pressureMethamphetamine causes the rapid heart rate

What is Amphetamine?

Amphetamine is a drug used to stimulate the central nervous system. It is used to treat Attention Deficit Hyperactivity Disorder(ADHD).

Disorders like narcolepsy and obesity are also treated with amphetamine. In 1887, the drug amphetamine was discovered. At first, it exists with two enantiomers.

They are Levoamphetamine and dextroamphetamine. In pure amine forms, the chemical is equally divided.

The term amphetamine is used to denote the enantiomers and also for single usage. In ancient days, the amphetamine drug was used to treat congestion and depression.

In athletic performance enhancers and cognitive enhancers, amphetamine has significant use. It reacts as an aphrodisiac and euphoriant.

In many countries, amphetamine is used as a prescribed drug. Due to heavy health risks, illegal amphetamine production is restricted.

Benzedrine is the first amphetamine pharmaceutical drug. It is used to treat various disorders. Racemic amphetamine is the current pharmaceutical amphetamine.

The amphetamine increases the monoamine and excitatory transmission in the brain. The amphetamine targets norepinephrine, which is present in the neurotransmitter.

Oral, insufflation, rectal, intravenous, and intramuscular are various routes for transmission. Amphetamine has 20% of protein binding.

The melting point of amphetamine is 11.3 °C. The boiling point of amphetamine is 203 °C. The chirality of amphetamine is a racemic mixture.

Amphetamine also causes many side effects.

amphetamine

What is Methamphetamine?

Methamphetamine is also a stimulant drug used to treat many disorders. It is used to treat the central nervous system.

Methamphetamine is a recreational drug that is used in second-line treatment. In 1893, the drug methamphetamine was discovered.

It exists in two enantiomers.

They are levo-methamphetamine and dextro-methamphetamine. Like amphetamine, methamphetamine is also equal in the base mixture in pure amine forms.

Methamphetamine is not a prescribed medicine in recent days. Due to its heavy neurotoxicity, it is not prescribed.

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Methamphetamine has its potential and recreational use. In racemic methamphetamine and dextro-methamphetamine it is trafficked.

In the united states and in many countries, methamphetamine is categorized as Schedule II, which is a controlled substance. In Asia and Oceania, the illegal manufacturing of methamphetamine occurs.

For treatment, the nasal decongestant is used in the United States. Methamphetamine is more effective and vigorous. But it is limited in many countries.

Desoxyn, Methedrine is the trade name for methamphetamine. It has high addiction liability. The melting point of methamphetamine is 170 °C.

The boiling point of methamphetamine is 212 °C. It causes many side effects.

It causes heart disease, glaucoma, and hyperthyroidism. Due to heavy usage, it also causes hypersensitivity in individuals.

Disorders like blood pressure, mania, psychosis, and thyroid problems. It affects pregnancy in women and affects infants.

methamphetamine scaled

Main differences Between Amphetamine and Methamphetamine

  1. The continuous usage of amphetamine causes changes in blood pressure, and methamphetamine causes rapid heart rate.
  2. Amphetamine is used for medical purposes, but methamphetamine is not used for medical purposes
  3. Comparatively, amphetamine is less vigorous, and methamphetamine is more vigorous.
  4. The effect of amphetamine drug will not last for a long time, but
    methamphetamine is long-lasting.
  5. When compared to amphetamine, methamphetamine is more effective.
Difference Between Amphetamine and Methamphetamine
References
  1. https://journals.sagepub.com/doi/abs/10.1177/108705470000300403
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc1974659/

Last Updated : 11 June, 2023

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10 thoughts on “Amphetamine vs Methamphetamine: Difference and Comparison”

  1. The insights into the potential health risks associated with the usage of methamphetamine are particularly important for raising awareness about the dangers of this drug.

    Reply
    • Absolutely, the impact of methamphetamine on health cannot be understated. This article does an excellent job in shedding light on this issue.

      Reply
  2. The detailed overview of amphetamine and methamphetamine provides valuable knowledge for understanding the therapeutic applications and potential risks associated with these drugs.

    Reply
  3. Interesting comparison between amphetamine and methamphetamine. I was not aware of the nuances in their medical applications and effects.

    Reply
  4. The comparison table and detailed information on the differences between amphetamine and methamphetamine provide a clear understanding of their distinctions.

    Reply
  5. The details about the chemical structure, medical use, and side effects of both amphetamine and methamphetamine are quite comprehensive.

    Reply

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