Difference Between Collagen and Retinol

These days almost every beauty cream contains a significant amount of Collagen and Retinol but most people have no idea how they both work on the skin. Is there any significant difference between Collagen and Retinol? No wonder that both of them are chemical properties also produced by our body cells up to certain age in females. Moving further we have penned down their uses for different purposes.

Collagen vs Retinol

The main difference between Collagen and Retinol is that Collagen is less effective on the skin in comparison to Retinol i.e. Collagen is a kind of protein present in our body structurally whereas Retinol is the Vitamin A present in our body for flawless skin that occurs in the meal we consume. Collagen penetrates the upper 2 layers of the skin and Retinol penetrates all layers of skin.

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The term Collagen refers to the structural protein located in connected tissue. It repairs the temporary damages to the skin overnight. Also, It slows down the signs of aging in the skin. Both Biochemical substances and structured protein are the properties of Collagen. In large quantities, Collagen is present in the corneas, the gut, intervertebral discs, blood vessels, and the dentin in teeth.

The term Retinol refers to the purest form of Vitamin A present in the human body to repair the damaged tissues in the skin and make the skin flawless. It stimulates the new productive skin cells and in addition to the same, it is much stronger than Collagen on the skin. Vitamin A1 is prominently referred to as Retinol since it has gained popularity in skin products.

Comparison Table Between Collagen and Retinol

Parameters of ComparisonCollagen Retinol
EffectsCollagen penetrates only the upper two layers of the skin.Retinol penetrates the deep tissues of the skin and is more effective on the skin.
Structure.The structure of Collagen is a helix created from polypeptides.The structure of Retinol is fat-soluble alcohol.
FormationIt is created from the Fibroblast cells which form Collagen.Formation of Retinol can be with the intake of carotenoids in food.
Demerits.The Collagen has the risk of Ehlers-Danlos syndrome to a person.Retinol has the risk of health issues if taken too much in food.
Weight or Mass.The molecular weight of Collagen is about 300000 g/mol.The molecular weight of Retinol is about 286,45 g/mol.

What is Collagen?

The Collagen has a helical-shaped structure consisting of three chains of protein subunits also having some covalent bonds. There are many types of Collagen found in the human body forming many skin tissues and repairing the skin temporarily. It is essential protein-making tissue of the body which heals the upper two layers of skin.

It is a very important part of the skin cells that do not break down easily and has some flexible properties. It is created with the help of special cells in the body prominently known as Fibroblasts. The combination of proline, lysine, sugars, and hydroxyl groups bonded together form fibroblasts cells in the body that produce the collagen protein.

Collagen is a structural protein found in the extracellular matrix located in various connected tissues of the skin and it is less effective on skin as compared to Retinol. It is the main component of connected tissues in the body. It makes up or produces about 25% to 35 % protein in a person. In the structure of Collagen mainly the amino acids which are bonded together are helix formation. They are included in the cartilage, bones, tendons, ligaments, and skin. The forms of Collagen and rigid and compliant.

What is Retinol?

The term Retinol refers to a type of Vitamin A1 usually present in skincare products to slow down the aging process in women. There are many types of Retinols are present in the market and before starting using them over the skin one must take advice from a dermatologist. An initially mild version of Retinol should be applied on the skin to refrain from any harm to the human skin. 

It is found in the various food items containing Vitamin A also treats the deficiency of Vitamin A in the human body. A very important use of Retinol is as a dietary supplement. It cures acne and other chronic skin conditions which live spot on the skin specifically on the face. Prevention of abnormal skin peeling and pigmentation can be removed with the help of Retinol. An Individual with severe acne required a high dose of Retinol in the skin.

Vitamin A is an unsaturated compound that contains Retinol and prevents skin aging after 30 years of human life. Retinol trick the body to think young. Skin turnovers the cells faster after intake of Retinol serum or gel. A teenager can use Retinol at an early age for the treatment of acne spots and dark spots.

Main Differences Between Collagen and Retinol

  1. Strongness: Collagen is less harsh on the skin whereas Retinol is harsher on the skin than Collagen.
  2. Usage: Collagen works on sensitive skin and skin break out due to retinol and on the other side Retinol works on the elimination of deep wrinkles on the skin.
  3. Results: The results of Collagen are overnight or short-term on the contrary Retinol gives long-term results on the skin.
  4. Benefits: Collagen gives flawless, plumpy skin whereas Retinol softens the skin and makes skin tone lighter.
  5. Commercial Purpose: Collagen is used for skin surgeries and reconstruction whereas Retinol is present in various Vitamin A supplements available over the counter.


For effective results, both products should not be used together for preventive side effects. The Collagen and Retinol always must be applied to the freshly washed face. Skin goes in some adjustment period after using Retinol initially. To make the effect last longer on the skin one must start with the basic form of Retinol over the skin.

The slow down of skin productive cell makes the skin looks older and collagen helps the connective tissue to repair the broken skin and helps to look younger. Collagen is a fibrous protein present in Vitamin A1 and this important substance is found in the human body. There are few side effects of both Collagen and Retinoids therefore one must ensure them before intake of these.


  1. https://www.sciencedirect.com/science/article/abs/pii/S019096228670248X
  2. https://www.tandfonline.com/doi/abs/10.3109/09546639909056013

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