Emgality vs AJOVY: Difference and Comparison

With time, the pharmaceutical industry has grown in size, and new research on various medicines and medications for small to significant disorders has emerged.

Key Takeaways

  1. Emgality and Ajovy are both medications used to prevent migraines.
  2. Emgality targets the calcitonin gene-related peptide (CGRP) pathway, while Ajovy targets the CGRP receptor.
  3. Emgality is administered monthly via injection, while Ajovy can be given monthly or quarterly.

Emgality vs AJOVY

The difference between Emgality and AJOVY is that Emgality is taken at 240mg at first for migraines, and afterwards, 120mg works well as well. For three months, 100mg injections were given simultaneously for headache episodic clusters. However, In the case of adults, AJOVY is primarily used as a migraine prevention measure. AJOVY 225mg is injected three times a month for three months.

Emgality vs AJOVY

Galcanezumab is the name of the drug’s primary constituent, which is sold under the Emgality brand. The FDA authorised emgality on September 27th of this year.

Fremanezumab is the medicine that is offered under the AJOVY brand. The FDA approved AJOVY on September 14th, 2018.

Comparison Table

Parameters of ComparisonEmgalityAJOVY
Half-life27 days 31 days
Drug IngredientGalcanezumab Fremanezumab
Approval dateSeptember 27, 2018September 14, 2018
Process of intakeSelf-injected into the subcutaneous layer via a syringe or prefilled pen.Injected into perfectly healthy skin and in the subcutaneous layer.
WorkingBy blocking, counteracting the effect of CGRP protein.By halting the activeness of calcitonin gene-related peptide protein.
Use in adultsTreatment of episodic clusters of ache in head and migraine. Preventive measure to Migraine.
Dosage240mg then 120mg for migraine, 100mg for headache episodic cluster. 225mg every month, quarterly.

What is Emgality?

Galcanezumab is the generic name for the active ingredient in the medication Emgality. On September 27th, 2018, the FDA authorised Emgality.

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Emgality has a 27-day half-life. Emgality is a drug that is used to treat adult migraines and episodic clusters of pain in the head. Emgality is prescribed for migraines at a dosage of 240 mg at first, then 120 mg.

Constipation, dizziness, itchy skin, welts, 18% injection site responses, and anti-drug antibodies are some of the side effects described by individuals after using the treatment (up to 12.5 per cent).

emgality scaled

What is AJOVY?

Ajovy is a type of brand-name medicine for adults who is available via prescription only, and who suffer from migraine headaches. It comes in the form of a prefilled syringe.

On September 14th, 2018, FDA approved AJOVY. In the subcutaneous layer of the upper arm, abdomen, and thighs, AJOVY is injected into places that aren’t indurated, bruised, sensitive, or red.

The medication fremanezumab, a monoclonal antibody, is contained in Ajovy. A monoclonal antibody is a type of medication which is made up of immune system cells.

ajovy scaled

Main Differences Between Emgality and AJOVY

  1. Emgality is used in the treatment of episodic clusters of aches in the head and migraine in adults. On the other hand, AJOVY is consumed as a preventive measure for Migraines in the case of adults.
  2. For migraine, Emgality is taken at 240mg in the beginning, and then 120mg works well too. Simultaneously for headache episodic cluster, 100mg injection for three consecutive months.
  1. https://search.informit.org/doi/pdf/10.3316/informit.150591692335224
  2. https://www.tandfonline.com/doi/abs/10.1080/19420862.2018.1556465

Last Updated : 13 July, 2023

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23 thoughts on “Emgality vs AJOVY: Difference and Comparison”

  1. The unique working mechanisms of Emgality and AJOVY make them distinct in their approach to treating migraines. The approval dates further add to their individuality.

  2. The detailed explanation of both Emgality and AJOVY is quite informative. The safety and efficacy of these drugs are crucial factors.

  3. The article offers a clear differentiation between Emgality and AJOVY, outlining their respective uses and treatment courses.

  4. The comparison table between Emgality and AJOVY is very helpful. It is great to see the fundamental differences in drug ingredients, half-life, and the process of intake.

  5. It’s interesting to see that Emgality and AJOVY target different parts of the CGRP pathway. The information provided in the article is quite thorough.

  6. It’s quite remarkable to see the specificity in drug dosage for Emgality and AJOVY. The application methods are also different, which contributes to their diverse usage.

  7. The detailed comparison table allows for a comprehensive understanding of Emgality and AJOVY, showcasing their unique attributes for clinical use.

    • The in-depth analysis of the side effects and drug composition is highly beneficial for patients considering these medications.

    • Absolutely, the comprehensive overview of these medications is immensely educational for evaluating their applications in clinical practice.

  8. The distinction in the treatment application and dosage for Emgality and AJOVY is quite striking. This article has provided meticulous details.

  9. The comparison between Emgality and AJOVY regarding the process of intake and working mechanism provides a valuable insight into how these drugs function differently.


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