Difference Between Prilosec and Prevacid

Prilosec and Prevacid both are effective PPIs for the treatment of gastroesophageal reflux disease or stomach ulcer. Prilosec and Prevacid both are PPI drugs, also known respectively as omeprazole and lansoprazole.

Both come in brand names and generic names. Although both medications are used for stomach ulcers as PPI, they also have some effect, use, and cost-related differences.

Prilosec vs Prevacid

The main difference between Prilosec and Prevacid is that Prilosec and Prevacid have two different generic names that are omeprazole and lansoprazole. The standard dosage is also different from each other. Both the drugs have different side effects. In the short term use, Prevacid is slightly more effective than Prilosec.

Prilosec and Prevacid

Prilosec is a proton pump inhibitor or PPI. It works by inhibiting the proton pumps in our stomach that produce acid.

It is also known as omeprazole, which is the generic name of the drug. It is used for the treatment of diseases like stomach ulcers, GERD, erosive esophagitis, etc.

This drug is not suggested by doctors in pregnancy as it can increase some risks.

Prevacid is also a PPI that is widely used in the treatment of GERD, ulcers, heartburn, the acid surplus in the stomach, etc. Lansoprazole is the generic name of Prevacid. Additionally, this drug has some side effects such as diarrhea, headache, nausea, stomach inflammation, etc.

This drug should be taken as prescribed by the doctor, usually once daily before having the meal.

Comparison Table Between Prilosec and Prevacid

Parameters of Comparison  Prilosec  Prevacid  
Conditions treated  Ulcers in the stomach, erosive esophagitis, etc.  Gastroesophageal reflux disease, heartburn, ulcers, etc.  
Generic names  Omeprazole  Lansoprazole  
Dosage  Two capsules daily (two times) for a week or 10 days. (Depends on the condition of the patient)  One capsule (15mg) per day for 4 weeks, 15 mg daily for long-term use.  
Side effects  Diarrhea, bone fracture, stomach problems, nausea, etc.  Drowsiness, headache, constipation, etc.  
Cost  Less expensive than Prevacid.  More expensive than Prilosec.  

What is Prilosec?

Prilosec, also known as omeprazole, is an effective drug used to treat the symptoms of gastroesophageal reflux disease and other complications of the stomach raid by excessive stomach acid. Omeprazole should be taken before a meal. One can also take it with any food or an empty stomach.

Prilosec is also used to treat frequent heartburn when acid reflux of the stomach happens. It is used for certain stomach and esophagitis problems.

But it is dangerous to use for immediate relief of heartburn. Prilosec is a very fast-acting drug, and it is very useful for long-term use.

Prilosec is available as a prescription. One can also buy it over the counter.

Prilosec also has some side effects like headache, stomach inflammation, bone fracture, diarrhea, nausea, etc. It can cause allergic reactions too.

People can also suffer from overdose symptoms such as irregular heartbeat, drowsiness, unclear vision, vomiting, nausea, dry mouth, sweating, etc.

This medicine comes in the form of 2-5 mg suspension, 10 mg suspension. 10mg, 20 mg, and 40 mg capsule forms are also available on the market. This drug should be stored in a dry and cool place, away from the sunlight and heat.

It can also be stored at room temperature.

What is Prevacid?

Prevacid, also known as lansoprazole, is an effective drug. It is generally used to treat stomach ulcers, GRED, etc.

It helps to control stomach acid and is also used to treat the disease like Zollinger Ellison syndrome. It also helps to reduce the symptoms, such as heartburn and difficulty in swallowing.

It can also cause some serious allergic reactions to people with allergies.

Some research shows that this drug can be used safely during pregnancy. This is usually taken before the meal.

You can also take medicine in the morning before eating your breakfast. It should always be taken as per the doctor’s directions.

Prevacid is indicated in adults for short-term treatment. People who are allergic to lansoprazole should avoid Prevacid.

Prevacid comes in capsules forms, so you have to swallow the whole not to chew. Patients can take it via a nasogastric tube if there is any difficulty in swallowing capsules for the patient.

It can be opened. This drug helps to heal acid damage to the stomach and helps to prevent cancer of the esophagus.

Prevacid may cause several side effects including, stomach pain, blood in urine, swelling, dizziness, diarrhea, irregular heart rate, coughing, joint pain, skin rashes, etc. It may take 1 to 4 days to take action, and antacids may be taken along with its medication if needed.

It is available in 15 mg and 30 mg capsules and 15mg and 30mg orally disintegrating tablets.

Main Differences Between Prilosec and Prevacid

  1. Prilosec is known as its generic name omeprazole. On the other hand, Prevacid is also known as lansoprazole.
  2. Prilosec is generally used for the treatment of the patient with duodenal ulcers, GERD, stomach ulcers and Zollinger Ellison syndrome. On the other hand, Prevacid treats ulcers, GERD, heartburn, and surplus acid.
  3. Prilosec is slightly less effective than Prevacid. Prevacid is best for short-term treatments.
  4. Privacid is more expensive than Prilosec.
  5. Prilosec is to be taken 2 times for 10 days daily. On the other hand, one can take Prevacid once a day for 4 weeks (15 mg) for short-term treatment.


Prilosec and Prevacid are both nearly identical PPI drugs. People with gastroesophageal reflux synonyms can be treated with this medication.

Prilosec and Prevacid both are FDA-approved proton pump inhibitor drugs, and they are safe to use. They contain almost similar active ingredients.

There are a lot of people who have used PPIs like omeprazole and lansoprazole for years. They are not the type of medications that can be used on a needed basis.

It takes time to take action and is suitable for long-term term usage. Though Prevacid can be taken as short-term treatments.

The most important thing is that you should always take this kind of medication under the supervision of a doctor.


  1. https://pdf.hres.ca/dpd_pm/00056519.PDF
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