Difference Between Syrup and Suspension

Medicines are available in many forms for human consumption. Some of them are tablets, capsules, syrups, suspensions, emulsions, injections, lozenges, etc. These are taken based on the compatibility of patients.

Syrup vs Suspension

The main difference between syrup and suspension is that syrup is a solution consisting of sugar that is readily dissolvable in other solvents, while the suspension is a biphasic liquid system containing insoluble solute particles in the liquid medium. The drug is completely soluble in syrup, while suspension consists of solid particles in the liquid phase.

Syrup vs Suspension

A syrup is a liquid dosage form consisting of sugar and active pharmaceutical ingredient being completely soluble in it. Syrups are a clear monophasic liquid system consisting of a homogeneously mixed active ingredient.

The particles are in motion as such that they can settle down in a bottle and can be re-dispersed when shaken. The distribution of the drug or the active pharmaceutical ingredient should be uniform when the suspension is shaken.

Comparison Table Between Syrup and Suspension

Parameters of Comparison SyrupSuspension
DefinitionMonophasic liquid dosage form consisting of sugar and active pharmaceutical ingredient which is completely soluble in it.Biphasic liquid dosage form consisting of particles that are not completely soluble in the liquid media.  
Solvent systemSyrups can be aqueous-based or alcoholic syrups (called elixirs).Suspensions are usually water-based systems.
Ideal forYoung children and the elderly are more compatible with syrup due to the sweet taste.Ideal for diabetic patients who cannot administer syrup due to the presence of sugar.  
PhasesA monophasic dosage form as the drug is completely dissolved.A biphasic dosage form as the solid particles are not completely dissolved.
Types (based on usage)Simple syrup, medicinal syrup, elixirs, flavoured syrupOral suspension, parenteral suspension, topically applied suspension(creams, lotions).

What is Syrup?

A syrup is a solution consisting of sugar and an active pharmaceutical ingredient completely dissolved in it. This solute is completely dissolved in the solvent, and the resulting mixture is called a solution which is homogeneous in nature.

The solute particles are evenly distributed throughout the solvent system. This is one of the major advantages of this formulation. 

Syrups can be aqueous-based systems or alcohol-based systems. The alcohol-based syrups are known as elixirs.

Syrups can be of different types. The simple syrup is a sucrose solution having a concentration of 66.66% sucrose in water (e.g., Syrup USP).

Syrup

What is Suspension?

Suspension is a colloidal system having solid particles undissolved in the liquid phase. The particle size of the solid particles in suspension is in the range of 1 μm.

This is the reason that suspensions are needed to be shaken before administration so that the particles get evenly distributed. All the suspensions have the instruction on their label: Shake well before use. 

The external phase is also known as the suspending medium. There are two types of suspension: flocculated and deflocculated.

Suspension

Main Differences Between Syrup and Suspension

  1. The syrup is a sugar solution consisting of uniformly distributed active pharmaceutical ingredients or drugs, while the suspension is a heterogenous mixture where the drugs are not completely dissolved in the liquid media.
  2. The solvent system can be aqueous or alcoholic, while suspensions are usually aqueous-based.
Difference Between Syrup and Suspension

Conclusion

There is an abundant dosage form available in the market. While choosing a specific dosage form for the patient, the doctor must have knowledge of all the available options, and the formulator must have a sound knowledge of each and every dosage form.

Syrups being sweet are more compatible for patients as they mask the bitter taste of the drug. Suspensions are also flavored and are often used for drugs that are insoluble in aqueous media.

References

  1. https://adc.bmj.com/content/98/9/725.short 
  2. https://jamanetwork.com/journals/jama/article-abstract/309326  
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