Difference Between Basal Cell and Squamous Cell Carcinoma

Cancer is a deadly disease that can affect any organ in the body, including the skin, chest, breasts, and lungs.

These can develop into serious illnesses if not diagnosed early enough, and people can die as a result.

Damaged cells begin to grow inside the human body instead of normal and healthy ones in this condition.

Both basal cell and squamous cell carcinoma are skin cancers caused by the sun’s damaging ultraviolet radiation.

Although basal cell and squamous cell carcinomas are rarely life-threatening, they can be aggressive if not detected and treated early.

To get rid of cancer’s devastating effects, proper therapy is essential.

Basal Cell vs Squamous Cell Carcinoma

The main difference between Basal Cell and Squamous Cell Carcinoma is that Basal Cell is more dangerous than squamous cell carcinoma. The basal cell carcinoma is found in the epidermis layer of the lower part of the skin, while the squamous cell carcinoma is found in the upper part of the uppermost layer.

Basal Cell vs Squamous Cell Carcinoma

Basal cell carcinoma is one type of dermis cancer that can affect the body when it meets harmful sun rays.

This cell does not affect the internal organs but can target bones if not diagnosed and treated on time. Otherwise, it poses the least amount of risk to the human body.

Squamous cell carcinoma is also a dermis cancer that develops when ultraviolet rays fall on the human skin.

This aberrant cell can affect the lips, back, and ear, despite its modest growth rate. It can target human lymph nodes and bones, and tumors of this cell begin as a harmless lump on the body.

Comparison Table Between Basal Cell and Squamous Cell Carcinoma

Parameters of ComparisonBasal Cell CarcinomaSquamous Cell Carcinoma
Develops inBasal cell tumor develops in the lower layer of skin.Squamous cell carcinoma affects the epidermis’ top layer.
AttacksThis aberrant cell assaults the skin on the outside but does not affect the interior organs.This cell can impact a person’s limbs, tissues, and bones.
HarmfulIt is more dangerous than squamous cell carcinoma since it can affect eight out of ten persons.This kind of skin cancer affects only one-fifth of the population. So, it’s the least harmful.
Warning SignsBasal cell growth on the skin causes red, itchy areas and unpleasant bumps.Reddish patches and horn-shaped lumps are warning symptoms of this cell.
TreatmentWhen symptoms are identified, see a doctor right away.If you notice any lumps or warts on your skin, go to the lab right once to get them examined.

What is Basal Cell Carcinoma?

Basal Cell Carcinoma ( BCC) is one kind of skin cancer. Therefore, its other name is basal cell cancer.

These cells first manifest themselves as painless red pimples around the nose.

This damaged cell starts to multiply in the human body due to the fall of direct harmful sun rays on the skin which directly affect human’s Deoxyribonucleic acid.

However, grows at a steady speed. People with weakened immune systems and fair skin are more likely to get this malignancy, but it is not life-threatening.

Warning signs of basal cell carcinoma attacking any human is that the person will suffer from the hard texture of the skin, reddish-brownish bumps on the face, back, shoulder, and other parts of the body.

One should not ignore such indications to stay disease-free.

Such cancer does not affect a person’s internal organs, but it can affect bones, limbs, and skin tissue if it progresses to a later stage.

So, if a human experiences symptoms, go to the lab right away to offer test samples to eliminate any doubts about the sickness.

It is yet to be determined whether or not sunscreen, which protects people from the sun’s harmful rays, is effective in preventing basal cell carcinoma skin cancer.

A doctor’s treatment may entail cutting the contaminated skin to remove the tumor cells.

What is Squamous Cell Carcinoma?

Squamous cell carcinoma is also a type of dermis cancer. Such infected cells start multiplying on the upper layer of the epidermis that is the surface of the skin of the human body.

Its other name is cutaneous squamous cell carcinoma.

The marks formed by this cancer appear to be an ulcer on the skin.

Metastasis is a cancer cell carrier agent that carries squamous cell carcinoma to distant body parts and is induced by direct bodily contact with harmful sun rays, similar to basal cell cancer.

People who have crossed 50 years of their and suffer from sunburn are more prone to this disease. In terms of gender, males are disproportionately affected.

Also, people who have a weak immune system and less melanin in their skin are affected by SCC.

Rough patches of skin, red-brown pimples on the body, sore scars, and warts are all symptoms of squamous cell carcinoma, which are similar to those of basal cell carcinoma.

Even though this cancer is not fatal, people should seek medical advice if they notice these symptoms.

Medical professionals have identified several treatments for this malignancy, including laser surgery, radiation therapy, Mohs surgery, lotions, and medicines for the skin.

On this crucial decision, a person can seek medical counsel.

Main Differences Between Basal Cell and Squamous Cell Carcinoma

  1. The basal cell cancer develops in the lower layer of the skin. On the contrary squamous cell, cancer develops on the surface of the skin of humans.
  2. Though both types of cancer occur due to the hazardous UV rays of the sun. But, the basal cell can cause a serious problem if detected late as compared to squamous cell carcinoma.
  3. Humans are mostly affected by basal cell cancer on the outside of their bodies. Squamous cell carcinoma can spread beneath the skin and into other regions of the body through metastasis.
  4. Basal cell carcinoma causes a dome-shaped pimple on the outside of the body, as well as reddish-brownish spider veins (telangiectasia) on the face. Squamous cancer cells, on the other hand, generate keratosis pilaris. That can also be caused if the keratin ratio in the follicles increases.
  5. Photodynamic therapy, freezing, and various operations are used to treat the former condition. Mohs surgery and electronic Skin Surface Brachytherapy are two treatments for squamous cell carcinoma.
Difference Between Basal Cell and Squamous Cell Carcinoma


Both basal cell carcinoma and squamous cell carcinoma are malignancies of the skin, although neither is fatal.

On the lower and upper layers of the dermis, basal cell cancer and squamous cell cancer develop.

These malignancies are treatable, but in some cases, chemotherapy with strong medications is required.

Infected persons may potentially lose their hair as a result of this treatment. Both types of cancers can be treated with certain drugs and surgeries.

Both have warning indications such as red lumps, pimples, and spider veins on the human body.

When a person notices something unusual, they should see a doctor right away.


  1. https://www.aafp.org/afp/2012/0715/p161
  2. https://www.sciencedirect.com/science/article/pii/S0165247805001586
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