NPH vs Regular Insulin: Difference and Comparison

Insulin is a hormone produced by beta cells in the pancreas that allows cells to take up glucose from the bloodstream.

Type 1 diabetes occurs when the immune system attacks the beta cells in the pancreas, halting the production of insulin.

Type 2 diabetes develops when high blood sugar levels over time damage these cells, rendering them unable to produce enough insulin to address blood sugar levels.

As a result, your muscles, organs, and other body tissues slowly starve, even though there is plenty of food available in your intestines.

NPH And Regular Insulin are used as a treatment for Type 1 diabetes and Type 2 diabetes that lowers blood glucose levels.

Both NPH And Regular Insulin are extremely similar, yet they are different from each other.

Key Takeaways

  1. NPH insulin is intermediate-acting insulin, while regular insulin is short-acting.
  2. NPH insulin has a slower onset and longer duration of action, providing blood sugar control for a more extended period.
  3. Regular insulin controls blood sugar levels before meals, while NPH insulin is combined with short-acting insulin to manage blood sugar throughout the day and night.

NPH vs Regular Insulin

Neutral protamine Hagedorn (NPH) insulin is a long-acting insulin that regulates blood sugar levels in diabetic people. This insulin lasts longer and slows down blood sugar levels. Its side effects include cough, nausea, pale and swollen skin. Regular insulin is responsible for lowering blood sugar levels in diabetic patients. It lasts for a short duration and has side effects of headache, dizziness and nausea.

NPH vs Regular Insulin

NPH (Neutral Protamine Hagedorn) insulin is found to be the combination of two insulins that can lower the blood glucose levels at a normal rate even when they are too high, moreover, NPH insulin is slower in time of onset, however, NPH lasts longer than any other insulins.

Regular insulin is found to lower the blood glucose levels rapidly when they are too high, and isophane insulin which works when things are fine with the amount of sugar in the bloodstream, moreover Regular insulin is faster in terms of onset and shorter in terms of duration.

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Comparison Table

Parameters of ComparisonNPHRegular Insulin
DefinitionNPH (Neutral Protamine Hagedorn) insulin is a type of long-acting insulin that slows down blood glucose levels.Regular insulin is the regular type of insulin that lowers blood glucose levels.
DurationNPH (Neutral Protamine Hagedorn) insulin lasts longer.Regular insulin is shorter in terms of duration.
OnsetNPH insulin is slower in time of onset.Regular insulin is faster in terms of onset.
ComponentNPH is a mixture that includes their versions of human and beef or pork insulins.Regular insulin is made up of Human insulin, beef insulin, and pork insulin.
Side effectsPale skin, cough, nausea, swollen and red skin.Dizziness, headache, nausea, and swollen skin

What is NPH?

NPH (Neutral Protamine Hagedorn) insulin is a long-acting form of rapid-acting insulin that can be used hours before and continued use for 24 hours after meals.

NPH insulin starts working in about four hours and continues working for up to 24 hours. There are many different types of insulin treatments available, but one of the most popular is NPH.

NPH (Neutral Protamine Hagedorn) is a combination of two types of insulin that is slower than regular insulin, moreover, due to the combination of two types of insulin together, NPH slows down absorption so that more time is available for NPH to have its effect on the blood sugar level.

NPH does not result in a rapid drop in blood glucose levels, and this might make NPH a less desirable option for those who need to control their diabetes with insulin doses.

NPH (Neutral Protamine Hagedorn) is as effective when used at the same time each day, moreover, NPH insulin is slower in time of onset and lasts longer than regular insulins.

NPH is also preferable to use if someone has been diagnosed with Type 2 diabetes. NPH is a mixture that includes their versions of human and beef or pork insulins.

nph

What is Regular Insulin?

Regular insulin is made up of three types of insulin molecules. Human insulin, beef insulin, and pork insulin are the three types found in normal human insulin.

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All three are combined to form regular human insulin vials, which are used to help keep blood sugar at its preferred level.

Regular human insulin, which lowers blood glucose levels when they are too high, and isophane insulin, which works when things are fine with the amount of sugar in the bloodstream, moreover Regular insulin is found to be shown effective when it is used at the same time each day.

Regular insulin starts to work in 15-20 minutes and peaks within an hour, but after three to five hours, regular insulin stops working.

It doesn’t last very long in your body, moreover, Regular insulin is faster in terms of onset and shorter in terms of duration.

The National Institute for Health and Care Excellence (NICE) considers regular insulin to be the only suitable treatment for managing type 1 diabetes in adults.

regular insulin

Main Differences Between NPH and Regular Insulin

  1. NPH (Neutral Protamine Hagedorn) insulin is a type of long-acting insulin that slows down blood glucose levels, whereas Regular insulin is the regular type of insulin that lowers blood glucose levels.
  2. NPH is a mixture that includes their versions of human and beef or pork insulins, whereas Regular insulin is made up of Human insulin, beef insulin, and pork insulin.
  3. NPH insulin lasts longer, whereas Regular insulin is shorter in terms of duration.
  4. NPH insulin is slower in time of onset, whereas Regular insulin is faster in terms of onset.
  5. NPH includes Side effects of Pale skin, cough, nausea, swollen and red skin, whereas Regular insulin includes Side effects of Dizziness, headache, nausea, and swollen skin.
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References
  1. https://link.springer.com/article/10.1007/s00125-004-1365-z
  2. https://www.nejm.org/doi/full/10.1056/nejm199211123272005

Last Updated : 04 September, 2023

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20 thoughts on “NPH vs Regular Insulin: Difference and Comparison”

  1. Insulin is a fascinating and complex hormone, its production and use in the body are crucial. Understanding the differences between NPH and Regular Insulin is essential for diabetic patients. This article provides a thorough explanation of their mechanisms and side effects.

    Reply
  2. The content of this article is beautifully articulated and rich with valuable insights into NPH and Regular Insulin. I appreciate the thorough examination of these essential treatments.

    Reply
    • This article lends itself to an intellectual discourse on the intricate nature of NPH and Regular Insulin, fostering a deeper understanding of their roles in diabetes treatment.

      Reply
  3. The information presented here is enlightening. The side-by-side comparison of NPH and Regular Insulin helps to clarify their distinctions and intended uses.

    Reply
    • I couldn’t agree more, Max. Understanding these differences is essential for diabetic patients to manage their condition effectively.

      Reply
    • This article serves as an informative resource for those seeking to comprehend the unique characteristics of NPH and Regular Insulin.

      Reply
  4. I found this post to be both educational and enlightening. The breakdown of the comparison table was particularly useful in understanding the differences between NPH and Regular Insulin.

    Reply
    • I agree, Mandy. It’s crucial to comprehend the variations between these insulins for better management of diabetes.

      Reply
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  7. The article provides a comprehensive overview of NPH and Regular Insulin, offering valuable insights into their respective roles in diabetes management.

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  8. It’s interesting to learn about the specific differences between NPH and Regular Insulin. This will be beneficial knowledge for individuals living with diabetes.

    Reply

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